FASEB CONFERENCE--FOLATE, B-12 & ONE CARBON METABOLISM

美国实验生物学学会联合会赞助了 自1982年以来举办了一系列夏季会议，取得了巨大成功。 这些都 每年在佛蒙特州萨克顿河的佛蒙特学院举行。 在这 申请我们要求支持一个关于叶酸的新会议， 维生素B12与一碳代谢 早就应该召开一次结合这三个研究领域的会议了。 每个 近年来，这些领域发展迅速， 发展理念 其中一些是：使用一氧化二氮， 维生素B12辅酶在灵长类动物中产生维生素B12缺乏， 人类，认识到多谷氨酸形式的叶酸是天然的 辅酶的形式和聚谷氨酸链的长度影响 反应的速度，以及老鼠自发地 当保持缺乏甲基的饮食时会发生肝癌。 虽然一些 已就个别专题举行了专门会议， 据我所知，最近没有任何一次会议试图将 在这些相关领域工作的人。 会议的形式将类似于戈登会议所用的形式。 研究会议;会议将持续4 1/2天，9个主要 会议由四名发言人组成。 因此，将有36个 特邀演讲人 此外，还将在 晚上. 出席会议的人数将限制在150人左右 参与者

The Federation of American Societies for Experimental Biology has sponsored a series of Summer Conferences since 1982 with great success. These have been held annually at Vermont Academy in Saxtons River, Vermont. In this application we are asking for support of a new conference on Folic Acid, Vitamin B12 and One-carbon Metabolism. A conference combining these three areas of research is long overdue. Each of these fields has grown rapidly in recent years with many exciting developments. Some of these are: the use of nitrous oxide to specifically inactivate B12 coenzymes to produce vitamin B12 deficiency in primates and humans, the recognition that polyglutamate forms of folate are the natural coenzyme forms and that the length of the polyglutamate chain influences the rate of the reaction, and the demonstration that rats spontaneously develop hepatomas when kept on a diet devoid of methyl groups. While some specialized meetings have been held devoted to the individual topics, we are aware of no recent single meeting which has attempted to bring together individuals working in these related fields. The format of the meeting will be similar to that used in the Gordon Research Conferences; the meeting will last 4 1/2 days with 9 major sessions consisting of four speakers each. Therefore, there will be 36 invited speakers. There will also be poster sessions reviewed in the evenings. Attendance at the conference will be limited to about 150 participants.