EXERCISE--AN INTERVENTION FOR FATIGUE IN CANCER PATIENTS

疲倦是接受化疗(CTX)患者最常见和最令人丧失能力的症状。初步研究已经报道了锻炼对疲劳和相关变量的好处，还没有人调查锻炼计划的时机与环磷酰胺疗程的关系。这项随机临床试验(RCT)的目的是测试系统性干预的有效性，即亲自我：疲劳控制计划，该计划包括书面疲劳和运动教学指南，以及针对疲劳管理的个性化运动训练计划。第二个目的是评估干预的时机(即，在CTX期间和之后)。第三个目的是确定在干预和不干预的情况下，与疲劳相关的变量，如活动水平、身体健康、睡眠障碍和抑郁是否存在差异。综合疲劳模型1为拟议的研究提供了框架。样本将包括219名乳腺癌、结直肠癌或前列腺癌患者，他们将开始接受CTX的第一个疗程。这项单盲随机对照试验涉及三组人，他们在三个主要数据收集点接受评估：基线(T1)、CTX完成(T2)和研究结束(T3)。第1组(EE)接受干预，直到CTX完成，直到研究结束。第二组(CE)接受标准护理，直到CTX完成，然后进行干预，直到研究结束。第三组(CC)接受标准护理，直到CTX完成，直到研究结束。样本将根据癌症诊断进行分层。当两组在T2或T3进行比较时，将使用ANCOVA与因变量的基线调整分数一起使用。需要对锻炼作为一种自我保健干预进行研究，以便确定锻炼的频率、强度、持续时间和时间。这项研究的结果将极大地有助于建立这一知识库。

Fatigue is the most common and disabling symptom of patients receiving chemotherapy (CTX). Preliminary studies have reported the benefits of exercise on fatigue and related variables, none have investigated the timing of the exercise program in relationship to the course of CTX. The purpose of this randomized clinical trial (RCT) is to test the effectiveness of a systematic intervention, the PRO-SELF: FATIGUE CONTROL Program that includes written fatigue and exercise teaching guides and an individually tailored exercise training program on the management of fatigue. A second purpose is to evaluate the timing of the intervention (i.e., during vs. after CTX). The third purpose is to determine if there are differences in fatigue-related variables of activity level, physical fitness, sleep disturbances and depression with and without the intervention. The Integrated Fatigue Model1 provides the framework for the proposed study. The sample will include 219 individuals with breast, colo-rectal or prostate cancers who are starting their first course of CTX. This single blind RCT involves three groups who are assessed at three major data collection points: baseline (Tl), completion of CTX (T2), and the end of the study (T3). Group 1 (EE) receives the intervention through to the completion of CTX and through to the end of study. Group 2 (CE) receives standard care through to the completion of CTX and then the intervention through to the end of the study. Group 3 (CC) receives standard care through to the completion of CTX and through to the end of the study. The sample will be stratified by cancer diagnoses. When the groups are compared at either T2 or T3, ANCOVA will be used with baseline adjusted scores of the dependent variables. Research is needed on exercise as a self-care intervention so that the frequency, intensity, duration, and timing of the exercises can be determined. The findings of this study will greatly assist in building this knowledge base.