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The Impact of Lymphedema on Overall and Local Functioning

淋巴水肿对整体和局部功能的影响

基本信息

批准号：
7283965
负责人：
MARYLIN J DODD
金额：
$ 22.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-05 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7283965
关键词：
Affect Aftercare Appearance Articular Range of Motion Attenuated Biolectric Impedance Cancer Survivor Clinical Clinical Research Condition Consensus Detection Diagnosis Discrimination Distress Early treatment Female Breast Carcinoma Frequencies Functional disorder Future Hand Health Personnel Hour Impairment Incidence Intervention Intervention Studies Laboratories Limb structure Liquid substance Literature Localized Lymphedema Manuals Measurement Measures Methods Morbidity - disease rate Motion Operative Surgical Procedures Patients Physical Fitness Physical Function Purpose Quality of life Questionnaires Radiation therapy Range Range of motion exercise Recording of previous events Reporting Risk Sampling Shoulder Spectrum Analysis Staging Stimulus Symptoms Techniques Testing Time Upper Extremity Upper arm Water Woman cancer surgery clinical Diagnosis experience extracellular fitness grasp impression malignant breast neoplasm oncology

项目摘要

DESCRIPTION (provided by applicant): Arm lymphedema may arise at any time after breast cancer surgery and/or radiation therapy. A wide range in incidence has been reported in the literature, but there is general consensus for 20-28%. Lymphedema can result in notable morbidity e.g., distress as to appearance, discomfort, and dysfunction. The overall hypothesis of the proposed study is that lymphedema detrimentally affects local functioning of the upper extremity of the affected arm, and consequently affects the overall health-related functioning in breast cancer survivors. The purposes/aims of this cross sectional correlational study are: 1. to determine the relationship between degree of lymphedema and local upper extremity (hand, arm, shoulder) functioning; 2. to determine the relationship between degree of lymphedema, lymphedema-associated symptoms, localized upper extremity functioning, and overall health-related functioning; 3. to determine the relationship between degree of lymphedema, lymphedema-associated symptoms, localized upper extremity functioning overall health-related functioning, and quality of life. The sample will include 300 women who are breast cancer survivors. The entire testing/measurement session will take 3-4 hours in the General Clinical Research Center at UCSF. The session will include: measurement of lymphedema using bioelectrical impedance spectroscopy, specifically, multiple frequency bioelectrical analysis (MFBIA), local upper extremity functioning, and overall health-related functioning tests, as well as questionnaires related to lymphedema-associated symptoms and quality of life. Correlational analyses are planned to answer the aims of this study. By using the MFBIA measurement and carefully detailing the local upper extremity dysfunction and overall functioning of these women, as well as the symptom experience and their quality of life, the study will make an important contribution to our understanding of lymphedema, and will inform future intervention studies.

描述(申请人提供)：乳腺癌手术和/或放射治疗后的任何时间都可能出现手臂淋巴水肿。文献报道的发病率范围很广，但普遍共识是20-28%。淋巴水肿可导致显著的发病率，例如，外貌不适、不适和功能障碍。这项拟议研究的总体假设是，淋巴水肿有害地影响受影响手臂上肢的局部功能，从而影响乳腺癌幸存者的整体健康相关功能。这项横断面相关研究的目的/目标是：1.确定淋巴水肿程度与局部上肢(手、臂、肩)功能的关系；2.确定淋巴水肿程度、淋巴水肿相关症状、局部上肢功能与总体健康相关功能之间的关系；3.确定淋巴水肿程度、淋巴水肿相关症状、局部上肢功能与整体健康相关功能以及生活质量之间的关系。样本将包括300名乳腺癌幸存者。整个测试/测量过程将在加州大学旧金山分校的综合临床研究中心进行3-4个小时。会议将包括：使用生物阻抗频谱测量淋巴水肿，特别是多频生物电分析(MFBIA)、局部上肢功能和总体健康相关功能测试，以及与淋巴水肿相关症状和生活质量相关的问卷调查。相关分析计划用来回答本研究的目的。通过使用MFBIA测量并仔细详细地描述这些女性的局部上肢功能障碍和整体功能，以及症状体验和她们的生活质量，这项研究将对我们理解淋巴水肿做出重要贡献，并将为未来的干预研究提供参考。