The Impact of Lymphedema on Overall and Local Functioning

描述（由申请人提供）：乳腺癌手术和/或放射治疗后，手臂淋巴水肿随时可能出现。文献报道的发病率范围很广，但普遍的共识是20-28%。淋巴水肿可导致显著的发病率，如外观窘迫、不适和功能障碍。本研究的总体假设是淋巴水肿对患肢上肢的局部功能产生不利影响，从而影响乳腺癌幸存者的整体健康相关功能。本横断面相关研究的目的是：1。确定淋巴水肿程度与局部上肢（手、臂、肩）功能的关系；2. 确定淋巴水肿程度、淋巴水肿相关症状、局部上肢功能和总体健康相关功能之间的关系；3. 确定淋巴水肿程度、淋巴水肿相关症状、局部上肢功能、总体健康相关功能和生活质量之间的关系。样本将包括300名乳腺癌幸存者。在加州大学旧金山分校的普通临床研究中心，整个测试/测量过程将花费3-4个小时。会议将包括：使用生物电阻抗谱测量淋巴水肿，特别是，多频生物电分析（MFBIA），局部上肢功能和整体健康相关功能测试，以及与淋巴水肿相关症状和生活质量相关的问卷调查。相关分析计划回答这个研究的目的。通过使用MFBIA测量并仔细详细描述这些女性的局部上肢功能障碍和整体功能，以及症状经历和生活质量，该研究将为我们对淋巴水肿的理解做出重要贡献，并为未来的干预研究提供信息。

DESCRIPTION (provided by applicant): Arm lymphedema may arise at any time after breast cancer surgery and/or radiation therapy. A wide range in incidence has been reported in the literature, but there is general consensus for 20-28%. Lymphedema can result in notable morbidity e.g., distress as to appearance, discomfort, and dysfunction. The overall hypothesis of the proposed study is that lymphedema detrimentally affects local functioning of the upper extremity of the affected arm, and consequently affects the overall health-related functioning in breast cancer survivors. The purposes/aims of this cross sectional correlational study are: 1. to determine the relationship between degree of lymphedema and local upper extremity (hand, arm, shoulder) functioning; 2. to determine the relationship between degree of lymphedema, lymphedema-associated symptoms, localized upper extremity functioning, and overall health-related functioning; 3. to determine the relationship between degree of lymphedema, lymphedema-associated symptoms, localized upper extremity functioning overall health-related functioning, and quality of life. The sample will include 300 women who are breast cancer survivors. The entire testing/measurement session will take 3-4 hours in the General Clinical Research Center at UCSF. The session will include: measurement of lymphedema using bioelectrical impedance spectroscopy, specifically, multiple frequency bioelectrical analysis (MFBIA), local upper extremity functioning, and overall health-related functioning tests, as well as questionnaires related to lymphedema-associated symptoms and quality of life. Correlational analyses are planned to answer the aims of this study. By using the MFBIA measurement and carefully detailing the local upper extremity dysfunction and overall functioning of these women, as well as the symptom experience and their quality of life, the study will make an important contribution to our understanding of lymphedema, and will inform future intervention studies.