NOVEL CELLULOSE COPOLYMERS FOR BIOMEDICAL APPLICATIONS

我们建议开发新的生物兼容生物材料，用于生物医学用途，特别是用于制备分离设备。新的生物材料可以通过高产率、高成本效益的专利工艺容易地获得，该工艺还允许制备一系列不同的组合物。来自初步研究的初步数据表明，新的生物材料构成了很有前途的膜材料。拟议的商业应用：由于血膜相互作用的有害后果，血液透析患者的发病率和死亡率仍然很高。新的高效血液透析膜将成为这一领域的一个重要里程碑。可用于全血的免疫吸附剂的开发应该为在体外免疫吸附过程中取得重大改进提供潜力。与传统的层析介质相比，这些血液相容基质可以使用，而不需要之前的血细胞和血浆分离步骤。

We are proposing the development of new biocompatible biomaterials for biomedical uses and specifically for the preparation of separation devices. The new biomaterials can be readily derived with a high yielding, cost-effective proprietary process that also permits the preparation of a range of different compositions. Preliminary data from pilot studies indicate that the new biomaterials constitute promising membrane materials. PROPOSED COMMERCIAL APPLICATIONS: Significant morbidity and mortality remain in hemodialysis patients due to the deleterious consequences of blood-membrane interactions. New efficacious hemodialysis membranes would constitute a major milestone in this field. The development of immunoadsorbents usable with whole blood should offer the potential for making significant improvements in extracorporeal immunoadsorption procedures. In contrast to traditional chromatographic media, these hemocompatible matrices could be used without requiring the previous step of the separation of blood cells and plasma.