New Fluorinated MRI Probes for Cell Imaging

用于细胞成像的新型氟化 MRI 探针

• 批准号: 6549921
• 负责人: MANSSUR YALPANI
• 金额: $ 11.75万
• 依托单位: CARBOMER, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6549921
• 关键词: bioimaging /biomedical imaging; biomaterial compatibility; bioreactors; cellular respiration; chemical synthesis; contrast media; drug design /synthesis /production; fluorine; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; oxygen consumption; tissue /cell culture

DESCRIPTION (provided by applicant):New bio compatible probes are proposed for magnetic resonance imaging (MRI). 19F based probes will be prepared that are more suitable than existing products for rapid and sensitive oxygen mapping using 19F MRI. These probes will be employed to assess in a model system the viability, metabolic rate and oxygen consumption rates of rat INS-1 cells as surrogates of human is lets for potential applications in diabetes therapy. Preliminary data from pilot studies indicate that these new probes are promising and constitute a viable approach for improved cell viability control.

描述（由申请人提供）：新的生物相容性探头用于磁共振成像（MRI）。将制备基于19 F的探头，其比现有产品更适合使用19 F MRI进行快速和灵敏的氧标测。这些探针将用于在模型系统中评估大鼠INS-1细胞的活力、代谢率和耗氧率，作为人INS的替代物，用于糖尿病治疗的潜在应用。初步研究的初步数据表明，这些新的探针是有前途的，并构成一个可行的方法，提高细胞活力控制。