ACTIVATED SODIUM CHANNELS IN HYPERTENSION

高血压中的激活钠通道

• 批准号: 6178131
• 负责人: DAVID Gene WARNOCK
• 金额: $ 27.72万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6178131
• 关键词: B lymphocyte; RNase protection assay; Xenopus oocyte; amiloride; angiotensin /renin /aldosterone hypertension; clinical research; cyclic AMP; dietary sodium; family genetics; human subject; insulin; nutrition related tag; pathogenic diet; polymerase chain reaction; protein kinase C; renal tubular transport; single cell analysis; sodium channel; tissue /cell culture; voltage /patch clamp

DESCRIPTION (Adapted from the Applicant's Abstract): This grant has three Specific Aims: Electrophysiologic studies of the activated Na+ channel phenotype in B lymphocytes from patients with hypertension, the expression of the Na+ channel phenotype in the oocyte expression system, and expression studies and cloning of the B lymphocyte Na+ channel subunits.

描述(改编自申请者摘要)：这笔赠款有三个 特定目标：激活的Na+通道的电生理学研究 高血压患者B淋巴细胞表型及其表达 在卵母细胞表达系统中的Na+通道表型，并表达 B淋巴细胞Na+通道亚基的研究与克隆

项目成果

Prevention, protection, and the intrarenal renin-angiotensin systems.

• DOI: 10.1053/snep.2001.26806
• 发表时间: 2001-11
• 期刊: Seminars in nephrology
• 影响因子: 3.3
• 作者: D. Warnock