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SEQUENCE SPECIFIC BINDING OF DNA BY A NOVEL COILED COIL

SEQUENCE SPECIFIC BINDING OF DNA BY A NOVEL COILED COIL
新型卷曲线圈对 DNA 的序列特异性结合
批准号：
6056028
负责人：
KEVIN M GUCKIAN
金额：
$3.09万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
未结题
起止时间：
2000-03-01 至
来源：
https://reporter.nih.gov/project-details/6056028
关键词：
DNA binding protein DNA footprinting circular dichroism peptide chemical synthesis protein binding protein engineering protein structure

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DESCRIPTION The sequence specific recognition of DNA by proteins is extremely important for many biological processes. Due to its importance new motifs which sequence specifically recognize DNA are useful in the design of therapeutics as well as in the construction of new proteins. This proposal outlines the design of a novel motif for the sequence specific recognition of DNA and its subsequent use in the design of a DNA dependent peptide ligase. This motif consists of a heterodimeric coiled coil in which one of the solvent exposed faces is design to recognize the major groove of the AP-1 site.
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SEQUENCE SPECIFIC BINDING OF DNA BY A NOVEL COILED COIL
  • 批准号：
    6363194
  • 项目类别：
  • 资助金额：
    $3.45万
  • 财政年份：
    2001
  • 负责人：
    KEVIN M GUCKIAN
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE
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