MICROSPHERES FOR IMPROVED BIOAVAILABILITY

微球可提高生物利用度

• 批准号: 6335436
• 负责人: Edith Mathiowitz
• 金额: $ 19.63万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6335436
• 关键词: alpha benzopyrone; beta galactosidase; drug design /synthesis /production; gel electrophoresis; gene therapy; high performance liquid chromatography; insulin; laboratory rat; method development; microcapsule; nanotechnology; paclitaxel; pharmacokinetics; plasmids; polymers; spectrometry

DESCRIPTION: The investigators propose to develop nanoparticulate biodegradable polymeric oral delivery systems for therapeutic agents representative of hydrophobic small molecules, proteins, and genes, and will study their uptake, as further described by their abstract: "Our project focuses on the development of nanoparticle-based, oral delivery systems, composed of biodegradable polymers, used to efficiently encapsulate and increase the bioavailability and uptake of three representative therapeutic agents from the most active fields of current research: small hydrophobic molecules (taxol), proteins (insulin) and genes. "Although much research has been performed with the first two systems, still there is a challenge to improve the oral bioavailability of these drugs. No product is commercially available on the market, particularly for the oral delivery of peptides and proteins. The last system is the most challenging one, since very little work has been done on oral delivery of genes. "Our hypothesis is that if we succeed in enhancing uptake of drug-loaded nanoparticles, then we may be able to enhance the bioavailability of each of the potential drug candidates. For taxol and insulin, we will target an increase in systemic bioavailability, while for plasmids the nature of he enhancement may be either local or systemic."

描述：研究人员提出开发纳米颗粒

项目成果

A novel polyethylene depot device for the study of PLGA and P(FASA) microspheres in vitro and in vivo.

• DOI: 10.1016/s0142-9612(02)00183-7
• 发表时间: 2002-11
• 期刊: Biomaterials
• 影响因子: 14
• 作者: M. Sandor;Joshua Harris;E. Mathiowitz

Transfection of HEK cells via DNA-loaded PLGA and P(FASA) nanospheres.

通过负载 DNA 的 PLGA 和 P(FASA) 纳米球转染 HEK 细胞。

• DOI: 10.1080/1061186021000038373
• 发表时间: 2002
• 期刊: Journal of drug targeting
• 影响因子: 4.5
• 作者: Sandor,M;Mehta,S;Harris,J;Thanos,C;Weston,P;Marshall,J;Mathiowitz,E
• 通讯作者: Mathiowitz,E

Effect of lecithin and MgCO3 as additives on the enzymatic activity of carbonic anhydrase encapsulated in poly(lactide-co-glycolide) (PLGA) microspheres.

• DOI: 10.1016/s0304-4165(02)00153-8
• 发表时间: 2002-02
• 期刊: Biochimica et biophysica acta
• 作者: M. Sandor;Alex Riechel;I. Kaplan;E. Mathiowitz

The role of foxg1 in the development of neural stem cells of the olfactory epithelium.

• DOI: 10.1111/j.1749-6632.2009.04372.x
• 发表时间: 2009-07
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Kawauchi S;Santos R;Kim J;Hollenbeck PL;Murray RC;Calof AL
• 通讯作者: Calof AL

Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome.

• DOI: 10.1371/journal.pgen.1000650
• 发表时间: 2009-09
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Kawauchi S;Calof AL;Santos R;Lopez-Burks ME;Young CM;Hoang MP;Chua A;Lao T;Lechner MS;Daniel JA;Nussenzweig A;Kitzes L;Yokomori K;Hallgrimsson B;Lander AD
• 通讯作者: Lander AD