CHEMISTRY OF ARTHROPOD SECRETIONS

昆虫和其他节肢动物占所有描述的一半以上 地球上的物种 有些是重要的病媒（即，采采 苍蝇、按蚊、锥蝽、蜱.），虽然许多 有的已发展成为农业，林业和家庭害虫。 化学在节肢动物的系统优势中起着关键作用。 地球;它是昆虫与植物相互作用的基础， 它们的同类，与动物宿主，和捕食者。 首席 这个项目的目标是阐明这些化学基础 交互. 昆虫和植物已经共同进化了数亿年， 这些群体之间的化学关系丰富， 各种各样。 我们的工作还将扩展到植物，在这些情况下， 利用植物毒素作为昆虫防御化合物， 信息素前体似乎很重要。 在这些情况下， 昆虫物种依赖于植物作为防御的来源 化合物，信息素，或其前体，天然产物 研究有关植物的化学成分。 具有生物活性的新型昆虫衍生物的合成 活动将是该计划的一个重要方面。 这是一 节肢动物化学研究的重要方面，因为合成服务于 不仅确认了”结构和立体化学，而且还提供了 足够数量的材料用于生物测定。总体目标 （1）提高我们对自然的认识 化学防御和通信，（2）提供新的基础 昆虫控制技术，可适用于疾病媒介， （3）发现新的化学物质， 药物和/或农用化学品开发。

Insects and other arthropods make up over half of all the described species on earth. Some are important as disease vectors (i.e., tsetse fly, anopheles mosquitoes, triatomine bugs, ticks ...), while many others have developed into agricultural, forest, and household pests. Chemistry plays a key role in the phyletic dominance of arthropods on earth; it is the basis for the interactions of insects with plants, with their conspecifics, with animal hosts, and with predators. The chief goal of this project is to elucidate the chemistry underlying these interactions. Insects and plants have been co-evolving for hundreds of millions of years, and the chemical relationships between these groups are rich and varied. Our work will also extend to plants in those instances where the utilization of plants toxins as insect defensive compounds and pheromone precursors seem to be important. In those instances where an insect species is dependent on plants as a source of defensive compounds, pheromones, or their precursors, the natural products chemistry of the relevant plant species will be studied. The synthesis of new insect-derived compounds showing biological activity will be an important facet of this program. This is an essential aspect of arthropod chemical research, since synthesis serves not only to confirm" structures and stereochemistry, but also supplies material in sufficient quantity for bioassays. The overall objectives of this program are: (1) to increase our understanding of natural chemical defense and communication, (2) to provide the basis for new insect control techniques which may be applicable to disease vectors of other pests, and (3) to discover new chemistry which may be useful in drug and/or agrochemical development.