DEPO PROVERA AND BONE MINERAL DENSITY IN ADOLESCENTS
DEPO PROVERA 与青少年骨矿物质密度
基本信息
- 批准号:6182442
- 负责人:
- 金额:$ 60.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-01 至 2004-08-31
- 项目状态:已结题
- 来源:
- 关键词:adolescence (12-20) age difference bone density calcium metabolism chemoprevention clinical research dosage forms drug adverse effect estradiol female female antifertility drug hormone therapy human subject human therapy evaluation longitudinal human study medroxyprogesterone sex hormones women's health
项目摘要
DESCRIPTION: (Adapted from Investigator's Abstract) The United States has one
of the highest adolescent pregnancy rates among industrialized nations. One
of the major contributing factors is inadequate contraception. A very
effective contraceptive method is depot-medroxyprogesterone acetate (DMPA)
which has become increasingly popular in this age group. Recent research in
adults has suggested a negative effect of DMPA on bone mineral density (BMD).
With decreased BMD, one's risk increases later for osteoporosis, a major
public health problem affecting millions of postmenopausal women every year.
Compromised BMD would appear to be a particular concern in adolescents, as
they normally accrue up to 40% of their total bone mineral content during this
period. In preliminary work, the investigators demonstrated a 3.0% decrease
in BMD in adolescent DMPA users over 2 years, compared with a 9.0% increase in
untreated controls (p<0.0001). A prospective cohort study of the effects of
DMPA on adolescent BMD, which will also include a double-blinded randomized
prevention component, is proposed. Bone density in 400 adolescent DMPA
initiators will be compared to their baseline values and to that of 300 and
120, oral and barrier contraceptive initiators, respectively, frequency
matched on age and race. Bone density will be measured every six months for a
maximum of two years. Bone density will also be measured at the time of
discontinuation of contraceptive method. To evaluate the protective effects
of estrogen on bone density, females in the DMPA treatment arm will be
randomly assigned to DMPA with estradiol (n=200) and DMPA without estradiol
(n=200). To examine the question of whether age modifies the effect of DMPA
on bone density, the investigators will evaluate the age-treatment interaction
between DMPA use and bone density among females of varying gynecologic ages.
Finally, sex hormone levels and indices of calcium metabolism will be compared
among the treatment groups in order to explore the biologic mechanisms
underlying BMD changes. The statistical analysis will estimate the effect of
DMPA on bone density while taking account of constant treatment
discontinuation throughout the study period.
描述:(改编自研究者摘要)美国有一个
是工业化国家中青少年怀孕率最高的国家之一。 一
其中一个主要因素是避孕措施不足。 一个非常
有效避孕方法是醋酸甲孕酮(DMPA)
在这个年龄段的人中越来越流行 最近的研究
成年人的研究表明DMPA对骨矿物质密度(BMD)有负面影响。
随着骨密度的降低,一个人以后患骨质疏松症的风险增加,
每年影响数百万绝经后妇女的公共卫生问题。
BMD受损似乎是青少年的一个特别问题,
在这一过程中,它们通常会积累高达40%的总骨矿物质含量,
期 在初步工作中,调查人员证明,
2年以上DMPA使用者的BMD增加了9.0%,
未处理的对照(p<0.0001)。 一项前瞻性队列研究,
DMPA对青少年BMD的影响,还将包括一项双盲随机
预防措施,提出。 400例DMPA青少年骨密度测定
启动器将与其基线值和300的基线值进行比较,
120,口服避孕药和屏障避孕药启动者,分别,频率
年龄和种族都匹配 每六个月测量一次骨密度,
最多两年。 还将在以下时间测量骨密度:
停止避孕方法。 为了评估保护效果,
雌激素对骨密度的影响,DMPA治疗组的女性将
随机分配至含雌二醇的DMPA组(n=200)和不含雌二醇的DMPA组
(n=200)。 研究年龄是否影响DMPA的作用
在骨密度方面,研究人员将评估年龄-治疗的相互作用,
DMPA使用与不同妇科年龄女性骨密度之间的关系。
最后,将比较性激素水平和钙代谢指标
以探讨其生物学机制
潜在的BMD变化。 统计分析将估计
DMPA对骨密度的影响
在整个研究期间停药。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BARBARA A. CROMER的其他文献
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{{ truncateString('BARBARA A. CROMER', 18)}}的其他基金
INTIMA-MEDIA THICKNESS (IMT) IN ADOLESCENT GIRLS: A FOLLOW UP
青春期女孩的内膜中层厚度 (IMT):随访
- 批准号:
7378028 - 财政年份:2006
- 资助金额:
$ 60.64万 - 项目类别:
DEPOT MEDROXYPROGESTERONE ACETATE AND BONE MINERAL DENSITY IN ADOLESCENTS
醋酸甲羟孕酮长效与青少年骨矿物质密度
- 批准号:
7378030 - 财政年份:2006
- 资助金额:
$ 60.64万 - 项目类别:
IMPACT ON BONE BY DIFFERENT LEVELS OF ESTROGEN IN ORAL CONTRACEPTIVE
口服避孕药中不同水平雌激素对骨骼的影响
- 批准号:
7377995 - 财政年份:2006
- 资助金额:
$ 60.64万 - 项目类别:
DEPO-PROVERA AND BONE MINERAL DENSITY IN ADOLESCENTS
DEPO-PROVERA 与青少年骨矿物质密度
- 批准号:
7202817 - 财政年份:2005
- 资助金额:
$ 60.64万 - 项目类别:
IMPACT ON BONE BY DIFFERENT LEVELS OF ESTROGEN IN ORAL CONTRACEPTIVES
口服避孕药中不同水平雌激素对骨骼的影响
- 批准号:
7202710 - 财政年份:2005
- 资助金额:
$ 60.64万 - 项目类别:
Intimal-medial thickness of the carotid arteries in adolescent girls
青春期女孩颈动脉内膜-中膜厚度
- 批准号:
6974899 - 财政年份:2004
- 资助金额:
$ 60.64万 - 项目类别:
Depo-Provera and bone mineral density in adolescents
Depo-Provera 和青少年骨矿物质密度
- 批准号:
6975026 - 财政年份:2004
- 资助金额:
$ 60.64万 - 项目类别:
Impact on bone by different levels of estrogen in oral contraceptives
口服避孕药中不同水平雌激素对骨骼的影响
- 批准号:
6974919 - 财政年份:2004
- 资助金额:
$ 60.64万 - 项目类别:
DEPO PROVERA AND BONE MINERAL DENSITY IN ADOLESCENTS
DEPO PROVERA 与青少年骨矿物质密度
- 批准号:
6594076 - 财政年份:1999
- 资助金额:
$ 60.64万 - 项目类别:
DEPO PROVERA AND BONE MINERAL DENSITY IN ADOLESCENTS
DEPO PROVERA 与青少年骨矿物质密度
- 批准号:
2679232 - 财政年份:1999
- 资助金额:
$ 60.64万 - 项目类别:
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