DEPOT MEDROXYPROGESTERONE ACETATE AND BONE MINERAL DENSITY IN ADOLESCENTS

醋酸甲羟孕酮长效与青少年骨矿物质密度

• 批准号: 7378030
• 负责人: BARBARA A. CROMER
• 金额: $ 0.11万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378030
• 关键词: DEPOT; MEDROXYPROGESTERONE; ACETATE; BONE; MINERAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In our previous study, we found that depot medroxyprogesterone acetate was associated with loss in bone mineral density in adolescent girls. From feedback of reviewers at the NIH to a competing renewal application, we deduce that any data that would give us information about the response of bone in girls who discontinue the method would be helpful in our demonstrating the importance of our examining the prospect of recovery of bone in these girls in our next funding cycle. Therefore, the objective of this study is to recruit the 9 girls identified in our previous studies, specifically those who dropped >5% in bone mineral density at the spine and who are not currently receiving the drug, for a repeat DEXA (dual energy absorptiometry) test. The purpose is to compare the current DEXA result with those that were obtained in the previous study.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在我们以前的研究中，我们发现长效醋酸甲羟孕酮与青春期女孩骨密度的损失有关。从NIH评审员的反馈到竞争性更新申请，我们推断，任何能为我们提供关于停止该方法的女孩骨反应信息的数据，都将有助于我们证明我们在下一个资助周期检查这些女孩骨恢复的前景的重要性。因此，本研究的目的是招募我们先前研究中确定的9名女孩，特别是那些脊柱骨密度下降>5%且目前未接受药物的女孩，进行重复DEXA（双能吸收法）测试。目的是将当前DEXA结果与先前研究中获得的结果进行比较。