AUTOMATED ANNOTATION OF GENOMIC DNA SEQUENCES
基因组 DNA 序列的自动注释
基本信息
- 批准号:6464604
- 负责人:
- 金额:$ 2.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-01-01 至 2002-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Adapted from the Investigator's Abstract): The major objective
of this project is to develop algorithms and software for performing
automated annotation of the coding regions of a large genomic DNA sequence.
The investigators will improve an analysis and annotation tool (AAT) that
uses fast database searching and rigorous alignment to locate exons of the
genomic sequence and to define intron-exon boundaries. The new annotation
software will be developed by integrating the improved AAT tool with gene
prediction programs. The annotation software assembles exons produced by
the improved AAT tool and exons predicted by the gene prediction programs
into gene structures. Some of the exons produced by the improved AAT are
used as constraints in the assembly.
Another goal of this project is to develop a rigorous program for producing
an optimal alignment between two DNA sequences. A novel feature about the
program is that the coding frame information will be incorporated into the
alignment model. An optimal alignment between two DNA sequences produced by
the program shows the correspondence of the codons of the sequences. Thus,
the alignment is also meaningful when the codons are translated into amino
acids.
描述(改编自研究者摘要):主要目的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xiaoqiu Huang其他文献
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