AUTOMATED ANNOTATION OF GENOMIC DNA SEQUENCES

描述(改编自《调查员摘要》)：主要目标 这个项目的目的是开发算法和软件来执行 大基因组DNA序列编码区的自动注释。 调查人员将改进分析和注释工具(AAT)， 使用快速的数据库搜索和严格的比对来定位 基因组测序和定义内含子-外显子边界。新的注解 将通过将改进的AAT工具与GENE集成来开发软件 预测程序。注释软件将产生的外显子汇编为 改进的AAT工具和基因预测程序预测外显子 转化为基因结构。由改进的AAT产生的一些外显子包括 用作部件中的约束。 这个项目的另一个目标是开发一个严格的生产计划 两个DNA序列之间的最佳比对。关于这部电影的一个新特点 方案是将编码帧信息合并到 对齐模型。产生的两个DNA序列之间的最优比对 该程序显示了序列密码子的对应关系。因此， 当密码子被翻译成氨基时，比对也是有意义的 酸。

DESCRIPTION (Adapted from the Investigator's Abstract): The major objective of this project is to develop algorithms and software for performing automated annotation of the coding regions of a large genomic DNA sequence. The investigators will improve an analysis and annotation tool (AAT) that uses fast database searching and rigorous alignment to locate exons of the genomic sequence and to define intron-exon boundaries. The new annotation software will be developed by integrating the improved AAT tool with gene prediction programs. The annotation software assembles exons produced by the improved AAT tool and exons predicted by the gene prediction programs into gene structures. Some of the exons produced by the improved AAT are used as constraints in the assembly. Another goal of this project is to develop a rigorous program for producing an optimal alignment between two DNA sequences. A novel feature about the program is that the coding frame information will be incorporated into the alignment model. An optimal alignment between two DNA sequences produced by the program shows the correspondence of the codons of the sequences. Thus, the alignment is also meaningful when the codons are translated into amino acids.