AUTOMATED ANNOTATION OF GENOMIC DNA SEQUENCES

基因组 DNA 序列的自动注释

• 批准号: 6138893
• 负责人: Xiaoqiu Huang
• 金额: $ 1.94万
• 依托单位: KECK GRADUATE INST OF APPLIED LIFE SCIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6138893
• 关键词: DNA; automated data processing; biomedical resource; computer assisted sequence analysis; computer program /software; mathematics; method development

DESCRIPTION (Adapted from the Investigator's Abstract): The major objective of this project is to develop algorithms and software for performing automated annotation of the coding regions of a large genomic DNA sequence. The investigators will improve an analysis and annotation tool (AAT) that uses fast database searching and rigorous alignment to locate exons of the genomic sequence and to define intron-exon boundaries. The new annotation software will be developed by integrating the improved AAT tool with gene prediction programs. The annotation software assembles exons produced by the improved AAT tool and exons predicted by the gene prediction programs into gene structures. Some of the exons produced by the improved AAT are used as constraints in the assembly. Another goal of this project is to develop a rigorous program for producing an optimal alignment between two DNA sequences. A novel feature about the program is that the coding frame information will be incorporated into the alignment model. An optimal alignment between two DNA sequences produced by the program shows the correspondence of the codons of the sequences. Thus, the alignment is also meaningful when the codons are translated into amino acids.

描述（改编自研究者摘要）：主要目的 这个项目的目的是开发算法和软件， 大基因组DNA序列编码区的自动注释。 研究人员将改进分析和注释工具（AAT）， 使用快速的数据库搜索和严格的比对来定位 基因组序列和定义内含子-外显子边界。 新注记 将改进后的AAT工具与基因整合，开发软件 预测程序。 注释软件组装由以下产生的外显子： 改进的AAT工具和基因预测程序预测的外显子 基因结构。 由改进的AAT产生的一些外显子是 用作部件中的约束。 该项目的另一个目标是制定一个严格的生产计划， 两个DNA序列之间的最佳比对。 一部关于 程序的一个重要特点是将编码帧信息并入到 对准模型 两个DNA序列之间的最佳比对， 该程序显示序列密码子的对应性。 因此，在本发明中， 当密码子被翻译成氨基时， acids.