NEURAL BASIS OF SEXUALLY DIMORPHIC BRAIN FUNCTION

性别二态性脑功能的神经基础

• 批准号: 6185349
• 负责人: Geert J. De Vries
• 金额: $ 10.57万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185349
• 关键词: amygdala; animal developmental psychology; arginine vasopressin; behavioral /social science research tag; brain mapping; central neural pathway /tract; developmental neurobiology; gender difference; hormone regulation /control mechanism; maternal behavior; messenger RNA; microdialysis; microinjections; parent offspring interaction; sex behavior; species difference; thalamus; vole

DESCRIPTION (adapted from applicant's abstract): This is a request for an Independent Scientist Award. This grant aims to add to our understanding of the neural basis of sexually dimorphic brain function by focusing on a sexually dimorphic system that has been implicated in parental and other sexually dimorphic behaviors and functions. The hypothesis driving this grant is that sex differences in the brain not only serve to generate sex differences in centrally regulated processes and behaviors, but also may enable males and females to show remarkably similar behaviors even though their physiological and hormonal conditions differ dramatically. It does this by studying the role of the sexually dimorphic vasopressin-immunoreactive projections of the bed nucleus of the stria terminalis and the medical amygdaloid nucleus in parental behavior. The strategy is to compare two species of voles: prairie voles (Microtus pennsylvanicus), a monogamous species in which both males and females provide parental care, and meadow voles (Microtus pennsylvanicus), a promiscuous species in which only females provide parental care. This strategy allows comparison of the AvP-ir projections not only between males and females but also between males that show different parental involvement. The research will entail psychopharmacological, hormonal and developmental manipulations, anatomical and cell biological analyses of reproduction-related changes, and behavioral observation. By virtue of its topic this study will contribute to understanding both sex differences in the brain and the neural basis of maternal as well as paternal behavior. The last contribution will be new to the field since virtually nothing is known about neural structures underlying paternal behavior. Research Career Development support is requested to free the PI form teaching and administrative duties. This will allow him to develop new anatomical, cellular, and molecular strategies to assess the contributions of the sexually dimorphic vasopressin projections to parental behavior.

描述（根据申请人的摘要改编）：这是对 独立科学家奖。 这项赠款旨在增加我们对 通过专注于一个性二态脑功能的神经基础 性二态系统与父母和其他有关 性二态行为和功能。 驱动这一假设 格兰特是大脑中的性别差异不仅有助于产生性别 中央管制过程和行为的差异，但也可能 使男性和女性能够表现出非常相似的行为 它们的生理和激素条件截然不同。 确实如此 通过研究性二态的作用 血管蛋白 - 免疫反应性的原核 末端和父母行为中的医学杏仁核。 这 策略是比较两种田鼠：草原田鼠（Microtus 宾夕法尼亚州），一种一夫一妻制的物种，男性和女性都 提供父母的护理和草地田鼠（Microtus Pennsylvanicus）， 仅女性提供父母护理的混杂物种。 这 策略允许比较AVP-IR的预测，不仅在男性之间 和女性，以及在表现出不同父母参与的男性之间。 该研究将需要心理药理，荷尔蒙和发展 操纵，解剖和细胞生物学分析 繁殖相关的变化和行为观察。 凭借 主题这项研究将有助于理解两种性别差异 孕产妇和父亲行为的大脑和神经基础。 最后的贡献将是对该领域的新事物，因为几乎没有什么是 关于父亲行为基础的神经结构的已知。 研究职业 要求开发支持以释放PI表格教学和 行政职责。 这将使他能够发展出新的解剖学， 细胞和分子策略评估 性二态加压素对父母行为的预测。