PREGNANCY, HYPOXIA AND TRANSCRIPTIONAL REGULATION OF NO

妊娠、缺氧和 NO 的转录调控

基本信息

  • 批准号:
    6182781
  • 负责人:
  • 金额:
    $ 15.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-06-01 至 2003-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Adapted from applicant's abstract) Dr. Margueritte White is an Assistant Professor of Medicine who has completed a joint clinical and research fellow-ship in Maternal Fetal Medicine through the Department of Obstetrics and Gynecology and the Cardiovascular Pulmonary Research Laboratory (CVP) at the University of Colorado. She is presently the recipient of the MIRS award which has supported her work in the CVP for the past 2 years and which ends in March 1998. She has recently completed a full year of graduate level courses required for Ph.D. candidates in the Molecular Biology Program (Advanced Molecular Biology, Molecular Genetics, Cell Biology and Molecular Virology). Through her fellowship to date, she has worked under the mentorship of Dr. Lorna Moore in CVP, Professor of Medicine, who is nationally and internationally recognized for her human and animal studies on the effects of high altitude on maternal vascular adjustments to pregnancy. This collaboration has resulted in two first author peer-reviewed publications, one manuscript in preparation, and four abstracts presented at national meetings. In addition, Dr. White has contributed to and been co-author on additional publications and abstracts emanating from this work (biographical sketch). Dr. White's research has focused on the role of nitric oxide in altering vascular reactivity during pregnancy under normoxic and chronically hypoxic conditions. She is extending her studies, thus far performed in guinea pig isolated vessel rings, to a cellular level in order to investigate molecular mechanisms by which pregnancy and chronic hypoxia influence transcriptional regulation of the endothelial nitric oxide synthase gene. Towards that end, in addition to completing graduate courses in molecular biology, she has established a collaborative and mentoring relationship with Dr. Benamin Perryman, Professor of Medicine with joint appointments in the Department of Cell and Structural Biology and the interdepartmental Molecular Biology Program. This collaboration has resulted in a recent abstract presentation at a national meeting. Dr. White will carry out the proposed studies under the direct supervision of Drs. Lorna Moore and Ben Perryman in whose laboratories there is considerable expertise in studying vascular biology and mechanisms of gene regulation, respectively. Dr. White's project brings together expertise from two nationally recognized centers of excellence in both research and training, the Cardiovascular Pulmonary Lab and the Molecular Biology Program both in adjoining buildings within the School of Medicine. The strength of Dr. White's proposal lies in her application of state of the art techniques in molecular biology to explore questions of physiologic importance regarding maternal vascular adjustments to pregnancy.
描述 (改编自申请人摘要)Margueritte白色博士是助理 医学教授谁已经完成了联合临床和研究 产科母婴医学研究金 心血管和肺研究实验室(CVP) 科罗拉多大学。 她目前是MIRS的接收者 该奖项支持了她过去两年在CVP的工作,并且 1998年3月结束。 她最近完成了一整年的研究生课程 博士学位所需的课程分子生物学专业的候选人 (高等分子生物学,分子遗传学,细胞生物学和分子生物学) 病毒学)。 通过她的奖学金迄今为止,她一直在工作, Lorna摩尔博士在CVP的指导,医学教授,谁是 国内和国际公认的人类和动物研究 高海拔对母体血管调节的影响, 怀孕 这一合作产生了两个第一作者 同行评审的出版物,一份正在编写的手稿,四份 在国家会议上提出的摘要。 此外,白色博士 为其他出版物和摘要撰稿并担任合著者 从这部作品中散发出来(传记素描)。 白色博士的研究 集中在一氧化氮在改变血管反应性中的作用, 在常氧和慢性缺氧条件下怀孕。 她是 扩展她的研究,迄今为止在豚鼠离体血管中进行 环,到细胞水平,以研究分子机制, 妊娠和慢性缺氧会影响 内皮型一氧化氮合酶基因。 为此,此外, 到完成分子生物学研究生课程,她建立了一个 与Benamin Perryman博士的合作和指导关系, 医学教授,在细胞系和 结构生物学和跨部门分子生物学计划。 这种合作导致了最近的一个抽象的介绍, 全国会议。 白色博士将根据 洛娜摩尔和本佩里曼博士的直接监督, 实验室有相当多的专业知识,在研究血管生物学 和基因调控机制。 白色博士的项目 汇集了两个国家认可的卓越中心的专业知识, 研究和培训,心血管肺实验室和 分子生物学课程都在毗邻的建筑物内的学校 药 白色博士的建议的优点在于她运用了 最先进的技术在分子生物学探索的问题 生理重要性的母体血管调整怀孕。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MARGUERITTE M WHITE其他文献

MARGUERITTE M WHITE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MARGUERITTE M WHITE', 18)}}的其他基金

PREGNANCY, HYPOXIA AND TRANSCRIPTIONAL REGULATION OF NO
妊娠、缺氧和 NO 的转录调控
  • 批准号:
    6536523
  • 财政年份:
    1998
  • 资助金额:
    $ 15.13万
  • 项目类别:
PREGNANCY, HYPOXIA AND TRANSCRIPTIONAL REGULATION OF NO
妊娠、缺氧和 NO 的转录调控
  • 批准号:
    6017199
  • 财政年份:
    1998
  • 资助金额:
    $ 15.13万
  • 项目类别:
PREGNANCY, HYPOXIA AND TRANSCRIPTIONAL REGULATION OF NO
妊娠、缺氧和 NO 的转录调控
  • 批准号:
    2652151
  • 财政年份:
    1998
  • 资助金额:
    $ 15.13万
  • 项目类别:
PREGNANCY, HYPOXIA AND TRANSCRIPTIONAL REGULATION OF NO
妊娠、缺氧和 NO 的转录调控
  • 批准号:
    6388461
  • 财政年份:
    1998
  • 资助金额:
    $ 15.13万
  • 项目类别:

相似海外基金

Living with Spontaneous Coronary Artery Dissection: A multicentre, patient-informed investigation
自发性冠状动脉夹层的生活:一项多中心、患者知情的调查
  • 批准号:
    481005
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
Development of nextgeneration cellular artificial blood vessels for coronary artery bypass surgery using bio-3D printer
使用生物 3D 打印机开发用于冠状动脉搭桥手术的下一代细胞人造血管
  • 批准号:
    23H02991
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Vascular age estimation by carotid artery echocardiography - development of a new method to improve the accuracy
通过颈动脉超声心动图估计血管年龄——开发提高准确性的新方法
  • 批准号:
    23K06864
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Quantitative assessment of carotid artery plaque vulnerability using dual-energy CT
双能CT定量评估颈动脉斑块易损性
  • 批准号:
    23K14915
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Multi-omics analysis on carotid artery stenosis for the biological mechanism of arteriosclerosis.
颈动脉狭窄的多组学分析动脉硬化的生物学机制。
  • 批准号:
    23K14718
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Uncertainty aware virtual treatment planning for peripheral pulmonary artery stenosis
外周肺动脉狭窄的不确定性虚拟治疗计划
  • 批准号:
    10734008
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
Whole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery disease
脂质的全基因组序列解释,以发现冠状动脉疾病的新基因和机制
  • 批准号:
    10722515
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
Molecular predictors of cardiovascular events and resilience in chronic coronary artery disease
心血管事件的分子预测因素和慢性冠状动脉疾病的恢复力
  • 批准号:
    10736587
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - UNIVERSITY OF MINNESOTA FIELD CENTER.
年轻人冠状动脉风险发展 (CARDIA) 研究 - 明尼苏达大学实地中心。
  • 批准号:
    10901060
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - COORDINATING CENTER (CC)
年轻人冠状动脉风险发展 (CARDIA) 研究 - 协调中心 (CC)
  • 批准号:
    10901063
  • 财政年份:
    2023
  • 资助金额:
    $ 15.13万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了