PREGNANCY, HYPOXIA AND TRANSCRIPTIONAL REGULATION OF NO

描述 (摘自申请者摘要)Margueritte White博士是一名助理 完成了联合临床和研究的医学教授 通过产科在母胎医学方面的研究 和妇科和心肺研究实验室(CVP)在 科罗拉多大学。她目前是MIRS的接受者 在过去两年中支持她在CVP的工作的奖项 将于1998年3月结束。她最近刚完成了整整一年的研究生学业。 分子生物学专业博士生所需的水平课程 高等分子生物学、分子遗传学、细胞生物学和分子 病毒学)。通过到目前为止的研究，她在 Lorna Moore博士在CVP的指导，医学教授， 她的人类和动物研究在国内和国际上都得到了认可 高原对母体血管适应的影响 怀孕了。这种合作产生了两位第一作者 同行评议的出版物，一份手稿正在筹备中，四份 在国家会议上提交的摘要。此外，怀特博士还有 为其他出版物和摘要投稿并与人合著 出自这部作品(传记素描)。怀特博士的研究已经 重点阐述了一氧化氮在改变血管反应性中的作用 在常氧和慢性低氧条件下怀孕。她是 扩展了她的研究，到目前为止是在豚鼠隔离血管上进行的 环，以在细胞水平上研究分子机制 妊娠和慢性低氧对转录调控的影响 内皮型一氧化氮合酶基因。为此，此外， 为了完成分子生物学的研究生课程，她建立了一个 与Benamin Perryman博士的合作和指导关系， 医学教授，细胞系和细胞系联合任命 结构生物学和跨部门分子生物学项目。 这种合作导致了最近在一个 全国会议。怀特博士将根据 直接监督洛娜·摩尔博士和本·佩里曼博士 实验室在研究血管生物学方面有相当多的专业知识 和基因调控机制。怀特博士的项目带来了 来自两个国家公认的卓越中心的专业知识在 研究和培训，心肺实验室和 分子生物学课程都在学校内的相邻建筑中 医学。怀特博士的建议的优势在于她应用了 分子生物学中探索问题的最新技术 孕期母体血管调节的生理学意义。

DESCRIPTION (Adapted from applicant's abstract) Dr. Margueritte White is an Assistant Professor of Medicine who has completed a joint clinical and research fellow-ship in Maternal Fetal Medicine through the Department of Obstetrics and Gynecology and the Cardiovascular Pulmonary Research Laboratory (CVP) at the University of Colorado. She is presently the recipient of the MIRS award which has supported her work in the CVP for the past 2 years and which ends in March 1998. She has recently completed a full year of graduate level courses required for Ph.D. candidates in the Molecular Biology Program (Advanced Molecular Biology, Molecular Genetics, Cell Biology and Molecular Virology). Through her fellowship to date, she has worked under the mentorship of Dr. Lorna Moore in CVP, Professor of Medicine, who is nationally and internationally recognized for her human and animal studies on the effects of high altitude on maternal vascular adjustments to pregnancy. This collaboration has resulted in two first author peer-reviewed publications, one manuscript in preparation, and four abstracts presented at national meetings. In addition, Dr. White has contributed to and been co-author on additional publications and abstracts emanating from this work (biographical sketch). Dr. White's research has focused on the role of nitric oxide in altering vascular reactivity during pregnancy under normoxic and chronically hypoxic conditions. She is extending her studies, thus far performed in guinea pig isolated vessel rings, to a cellular level in order to investigate molecular mechanisms by which pregnancy and chronic hypoxia influence transcriptional regulation of the endothelial nitric oxide synthase gene. Towards that end, in addition to completing graduate courses in molecular biology, she has established a collaborative and mentoring relationship with Dr. Benamin Perryman, Professor of Medicine with joint appointments in the Department of Cell and Structural Biology and the interdepartmental Molecular Biology Program. This collaboration has resulted in a recent abstract presentation at a national meeting. Dr. White will carry out the proposed studies under the direct supervision of Drs. Lorna Moore and Ben Perryman in whose laboratories there is considerable expertise in studying vascular biology and mechanisms of gene regulation, respectively. Dr. White's project brings together expertise from two nationally recognized centers of excellence in both research and training, the Cardiovascular Pulmonary Lab and the Molecular Biology Program both in adjoining buildings within the School of Medicine. The strength of Dr. White's proposal lies in her application of state of the art techniques in molecular biology to explore questions of physiologic importance regarding maternal vascular adjustments to pregnancy.