COGNITIVE NEUROSCIENCE OF DEMENTIA

在10年的PI研究认知障碍后， 中风，和一些最近的初步工作，认知在阿尔茨海默氏症的 疾病（AD），我决定把我的注意力更充分地转向 痴呆症尽管认知神经科学通常 专注于局部脑损伤，我相信AD和其他 痴呆症，包括帕金森病、亨廷顿病和 语义性痴呆，有很多东西可以教我们关于 正常思维及其神经基质，特别是关于 语义记忆和视觉认知，我的两个专业领域。 此外，痴呆症是一个主要的公共卫生问题， 而认知神经科学的方法可能有助于 来解决这个问题。因此，我请求支持， 进行五年的学习，研究和职业发展， 痴呆症的认知神经科学在此期间，我将执行 拟对AD患者的语义记忆和视觉认知进行研究 同时了解更多关于AD和其他痴呆症的知识。我的目标是 在研究痴呆症方面变得像我现在一样有能力 研究局灶性脑损伤，从而为我们的基础科学做出贡献 对痴呆症的了解和诊断的进展， 管理这些疾病。

After 10 years as a PI in research on cognitive impairments following stroke, and some recent preliminary work on cognition in AIzheimer's disease (AD), l have decided to turn my attention more fully towards the dementias. Although cognitive neuroscience has generally concentrated on focal brain damage, I believe that AD and other dementias, including Parkinson's disease, Huntington's disease and semantic dementia, have much to teach us about the functioning of the normal mind and its neural substrates, particularly with respect to semantic memory and visual cognition, my two areas of specialization. In addition, the dementias represent a major public health problem, and the cognitive neuroscience approach may be able to contribute towards solutions to this problem. I am therefore requesting support to undertake five years of study, research, and career development in the cognitive neuroscience of dementia. During this period I will carry out the proposed research on semantic memory and visual cognition in AD while learning more about AD and other dementias. My goal is to become as competent in research on dementia as I am now in research on focal brain damage, and thereby to contribute to our basic-science understanding of the dementias and to advances in the diagnosis and management of these diseases.