APOLIPOPROTEIN B VARIATION AND CORONARY HEART DISEASE RISK IN AFRICAN AMERICANS

众多流行病学研究的普遍共识是，改变 血浆脂蛋白水平是发病的重要危险因素 和心血管疾病(CHD)的严重性。载脂蛋白(Apo)。 脂蛋白的结构成分。也被描述为风险 冠心病的危险因素。作为低密度脂蛋白的配体- 载脂蛋白B受体是一种重要的致动脉粥样硬化因子。这 人们的兴趣导致了对载脂蛋白B基因影响的几项研究 几个民族人群配体和脂蛋白水平的多态性 包括高加索人、日本人、中国人和尼日利亚人。在现在 我们将测试载脂蛋白B基因变异的假设 影响非裔美国人血浆数量性状的变异性。 将进行的具体活动包括：1.验证假设。 建立一个由2000名随机选择的无关人员组成的登记处 居住在18岁至65岁之间的非裔美国人 阿拉巴马州12个黑带县；2.收集研究数据 登记的参与者：冠心病的风险因素，包括LIP， 脂蛋白、载脂蛋白水平：其他人口学变量包括 年龄、性别、体重、身高等生活方式特征：3。 在登记处的个人中确定载脂蛋白的分布 重组DNA分析确定的B单倍型：和4.进行 载脂蛋白B对血脂和脂蛋白影响的统计分析 来自阿拉巴马州黑带县的非裔美国人的水平。 拟议工作的结果将提供证据，说明 载脂蛋白B基因多态性对冠心病血浆危险因素的影响 非裔美国人。作为对参与者的激励，参与者将 使用Pen-3模式接受营养教育干预以减少 罹患冠心病的风险，或者，如果已经存在这种疾病的影响。 这项工作还将提供必要的证据，以确定之前 已发表的载脂蛋白B作为冠心病危险因素重要性的报告 尼日利亚黑人可以延伸到美国黑人。的注册处 来自阿拉巴马州12个黑带县的个人将提供 对CHD和CHD队列研究感兴趣的科学家的有用资源 非裔美国人的其他疾病。

A general consensus of numerous epidemiological studies is that altered plasma lipoprotein levels is a significant risk factor for the incidence and severity of cardiovascular diseases (CHD). Apolipoproteins (apo). structural components of lipoproteins. have also been described as risk factors for CHD. As a ligand for the low density lipoprotein (LDL)- receptor, apo B is of strong interest as an atherogenic factor. This interest has led to several investigations of the effect of apo B gene polymorphism on ligand and lipoprotein levels in several ethnic groups including Caucasians, Japanese, Chinese and Nigerians. In the present project we will test the hypothesis that genetic variation in apo B affects variability in plasma quantitative traits in African Americans. Specific activities will be conducted to test the hypothesis include: 1. Establish a registry consisting of 2000 randomly selected unrelated African American subjects between the ages of 18 and 65 who are residents of 12 Black Belt counties in Alabama; 2. Collect data on the study participants in the registry: Risk factors for CHD including lip, lipoprotein, apolipoprotein levels: other demographic variable including age, gender, weight, height, and other life style characteristics: 3. Determine within the individuals in the registry, the distribution of apo B haplotypes defined by recombinant DNA analysis: and 4. Conduct statistical analysis of the impact of apo B on lipid and lipoprotein levels in African Americans from the black-belt counties of Alabama. The results of the proposed work will provide evidence as to the impact of apo B gene polymorphism on difference in plasma risk factors for CHD in African Americans. As an incentive for participation, participants will receive nutritional education intervention using the Pen-3 Model to reduce the risk of developing CHD or, if already present effects of the disease. The work will also provide evidence necessary to determine if previously published reports of the significance of apo B as a CHD risk factor in Nigerian blacks can be extended to American blacks. The registry of individuals from the 12 Black Belt counties in Alabama will provide a useful resource for scientists interested in cohort studies of CHD and other diseases in African Americans.