Genome Analyses of the Incidence of Malignant Histiocytosis in the Flat-Coated Re

平涂 Re 中恶性组织细胞增多症发病率的基因组分析

• 批准号: 8256212
• 负责人: Edward J Smith
• 金额: $ 2.59万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-09 至 2012-04-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256212
• 关键词: Address; Affect; Animal Model; Biology; Birds; Breeding; Candidate Disease Gene; Canis familiaris; Cardiomyopathies; Characteristics; Chromosome Mapping; Clinical; Collaborations; Comparative Study; Competence; Development; Disease; Fellowship; Genes; Genetic; Genome; Genomics; Genotype; Health; Histology; Human; Human Characteristics; Incidence; Inherited; Investigation; Knowledge; Laboratories; Lead; Malignant Neoplasms; Malignant histiocytosis; Maps; Mitochondria; Modeling; Mutation; Oxidative Stress; Phenotype; Research; Research Training; Resources; Role; Structure; Training; Vertebrates; Virginia; Work; abstracting; base; cancer genetics; companion animal; comparative; dog genome; experience; genetic pedigree; genome wide association study; human disease; programs; sarcoma; skills

DESCRIPTION (provided by applicant): The research training fellowship will enable Dr. Ed Smith to establish a working collaboration with Dr. Elaine Ostrander's group at the NHGRI's Cancer Genetics Branch, a premier Comparative Canine Genomics Research lab in the world. The research training will help him extend investigations in his laboratory at Virginia Tech beyond candidate gene-based disease mapping for phenotypes like oxidative stress and the role of the mitochondria in diseases. In the past five years, his lab has used birds to investigate the genetics of cardiomyopathy and oxidative stress. Dr. Ostrander's lab uses diverse approaches to identify genes associated with phenotypic differences in dogs that would be useful in his future research that will include dogs and sarcomas. The overall research objective is to identify genomic regions associated with the incidence of malignant histiocytosis (MH) in the Flat Coated Retriever dog. Identification of these regions using genome wide association studies will provide a resource for fine mapping and gene identification for a sarcoma that also affects humans. The research training will help the fellow develop skills for working with the dog and to establish independent research to understand the hereditary basis of MH. PUBLIC HEALTH RELEVANCE: Dog pedigrees are large, multigenerational, and the result of directed matings, all of which favor the expression of recessive disorders such as cancer. The clinical presentation, histology, and biology of many canine cancers very closely parallel those of human malignancies; comparative studies of canine and human cancer will be of significant clinical benefit to the health of both humans and companion animals.

描述(由申请人提供)：研究培训奖学金将使Ed Smith博士能够在NHGRI的癌症遗传学分支机构与Elaine Ostrander博士的团队建立工作合作关系，NHGRI癌症遗传学分支机构是世界上一流的犬类比较基因组研究实验室。研究培训将帮助他在弗吉尼亚理工大学的实验室扩大研究范围，超越基于候选基因的疾病图谱，以确定氧化应激和线粒体在疾病中的作用等表型。在过去的五年里，他的实验室用鸟类进行了研究 心肌病和氧化应激的遗传学。奥斯特兰德博士的实验室使用不同的方法来识别与狗的表型差异相关的基因，这在他未来将包括狗和肉瘤的研究中将是有用的。总体研究目标是确定与扁平被毛寻回犬恶性组织细胞增生症(MH)发生率相关的基因组区域。使用全基因组关联研究识别这些区域将为精细定位和识别也影响人类的肉瘤提供资源。研究培训将帮助研究员发展与狗的工作技能，并建立独立的研究，以了解MH的遗传基础。 公共卫生相关性：犬类谱系庞大，多代交配，是定向交配的结果，所有这些都有利于表达隐性疾病，如癌症。许多犬癌的临床表现、组织学和生物学与人类恶性肿瘤非常相似；对犬癌和人类癌症的比较研究将对人类和同伴动物的健康有重大的临床益处。