VULNERABLE PLAQUE IDENTIFICATION BY NEAR-IR SPECTROSCOPY

通过近红外光谱法识别易损斑块

• 批准号: 6223604
• 负责人: ERIC S RYAN
• 金额: $ 31.34万
• 依托单位: INFRAREDX
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-29 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6223604
• 关键词: atherosclerotic plaque; bioimaging /biomedical imaging; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; catheterization; diagnosis design /evaluation; histology; human tissue; infrared spectrometry; laboratory rabbit; postmortem

We have demonstrated that the near-infrared system can successfully identify vulnerable plaques in aortic specimens from human autopsies. A company InfraReDx, has been formed to develop a catheter, light source, and detector system for clinical use. Because extensive preliminary data are available, we have chosen the Fast Track application. We have the following specific aims: 1. To perform infrared and histology correlations in human coronary artery tissue in approximately 150 specimens from 10 autopsy cases. 2. To develop a near-infrared catheter, light source and detection system for use in rabbits. 3. To utilize the system in a study of 20 cholesterol-fed rabbits to detect vulnerable aortic plaque. We anticipate that we will achieve sensitivity and specificities > 75% to identify plaques in the rabbit study, thus setting the stage for use in patients in Phase II of this application. PROPOSED COMMERCIAL APPLICATIONS: In addition to the identification of vulnerable plaque usage, the spectroscopy method is likely to be of benefit for multiple other diagnostic uses. These include diagnosis of tissue in the lungs, bladder, GI tract, and central nervous system. InfraReDx will develop these applications after the work for detection of vulnerable plaque is completed.

我们已经证明，近红外系统可以成功识别人体尸检主动脉标本中的易损斑块。 InfraReDx 公司已成立，致力于开发临床使用的导管、光源和检测器系统。由于可以获得大量的初步数据，我们选择了快速通道应用程序。我们有以下具体目标： 1. 对来自 10 个尸检病例的约 150 个标本的人体冠状动脉组织进行红外和组织学相关性分析。 2. 开发兔用近红外导管、光源及检测系统。 3. 利用该系统对 20 只喂食胆固醇的兔子进行研究，以检测易损主动脉斑块。我们预计，在兔子研究中，我们将实现> 75% 的敏感性和特异性来识别斑块，从而为该应用的 II 期患者使用奠定基础。拟议的商业应用：除了识别易损斑块用途之外，光谱方法可能还有利于多种其他诊断用途。其中包括肺、膀胱、胃肠道和中枢神经系统组织的诊断。 InfraReDx 将在易损斑块检测工作完成后开发这些应用程序。