IMPROVED STEREOTAXIC INSTRUMENTATION AND METHODOLOGIES

描述（研究者摘要）：实验中的许多程序 神经科学依赖于准确和精确的手术途径， 大脑中的特定结构，参考已知的地标， 头骨和关于大脑结构的三维信息， 发表在立体定位图谱上。 目前的立体定位仪器已经看到了从日期的变化不大 它的原始设计，大约35年前。 在此期间， 机床工业在精度和精度方面取得了巨大的进步， 基本机械机构的精度。 本项目的目的是确定准确度和精密度 可以通过立体定位仪器获得， 使用现代机床原理完全重新设计。 这个新 设计包括一个精密的表面板，提供可靠的 平面基准 第二，将研制新型通用机械手 使用精确的线性刻度和数字读数， 1微米。 最后，自动分度工具保持器将允许 用户可互换定心镜、钻头和电极夹持器， 一个共同的垂直轴。 预计这一工具将改善 立体定位手术的准确性提高了5至20倍;这些 结果将由独立的校准实验室进行验证 经NIST认证。 拟议商业应用：不可用

DESCRIPTION (Investigator's Abstract): Many procedures in experimental neuroscience depend upon accurate and precise surgical access to specific structures in the brain, in reference to known landmarks on the skull and three-dimensional information about brain structures as published in stereotaxic atlases. The current stereotaxic instrument has seen little change from the date of its original design, about 35 years ago. In the meantime, the machine tool industry has seen dramatic advances in the accuracy and precision of basic mechanical mechanisms. The purpose of this project is to determine the accuracy and precision that might be obtained with a stereotaxic instrument that has been completely re-designed using modern machine tool principles. This new design includes a precision surface plate which provides a reliable planar datum. Second, a new universal manipulator will be developed using precision linear scales and digital readouts with a resolution of 1 micron. Finally, an automatic indexing tool holder will allow the user to interchange centering scopes, drills, and electrode holders on a common vertical axis. This instrument is expected to improve the accuracy of stereotaxic surgery by a factor of 5- to 20-fold; these results will be verified by an independent calibration laboratory accredited by the NIST. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE