OLFACTORY ERPS & FRONTO-LIMBIC PATHOLOGY IN SCHIZOPHRENI

嗅觉ERPS

• 批准号: 6186770
• 负责人: BRUCE I TURETSKY
• 金额: $ 26.45万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6186770
• 关键词: brain electrical activity; clinical research; evoked potentials; family genetics; frontal lobe /cortex; human subject; limbic system; longitudinal human study; magnetic resonance imaging; neuropathology; neuropsychology; olfactions; olfactory disorder; olfactory lobe; psychophysics; schizophrenia; siblings

DESCRIPTION: (Verbatim from the Applicant's Abstract) There is growing evidence to suggest that schizophrenia is a neurobehavioral disorder that affects fronto-temporal areas of the brain. A relatively neglected, but in many ways ideal, probe of the fronto-limbic system is olfaction. Olfactory processing is mediated by limbic structures implicated in the pathophysiology of schizophrenia. The olfactory system is unique in that only one synapse lies between peripheral receptors and sensory cortex, providing one of the most direct links between the brain and environment. Patients with schizophrenia have significant olfactory deficits. Unlike the relatively static pattern of cognitive deficits seen over the course of illness, though, olfactory abilities appear to decline in linear fashion, independent of normal aging and gender effects. However, family studies have also demonstrated marked deficits in olfactory identification in unaffected first-degree relatives of schizophrenic probands. It would seem, therefore, that olfactory brain regions are affected by genetically-mediated developmental, as well as neurodegenerative processes. In this project, we will investigate the physiological and anatomical correlates of olfactory dysfunction, longitudinally, in patients, siblings and controls. We will build on prior psychophysical work to include the integrated assessment of psychophysical, psychophysiological and volumetric measures of olfactory structure and function. We will study 40 patients with schizophrenia, 40- otherwise healthy siblings and 40 unrelated controls. Physiological data will be acquired using a unique and previously unavailable assessment tool, unilateral olfactory event-related potentials (ERPs), with high density electrode arrays and current source and dipole localization analytic methods. Psychophysical olfactory test data and volumetric MRI measurements of olfactory cortical regions and the olfactory bulbs and tracts will also be obtained. All testing will be repeated after a two-year interval, to assess any differential decline in olfactory abilities in the patietns, attributed to their disease state. The relationship of these olfactory measures to clinical, cognitive and affective symptoms will be investigated. Given the relevance of the neural substrate, we anticipate that a comprehensive assessment of olfactory integrity will illuminate important aspects of the neuropathology of schizophrenia and could be especially helpful in distinguishing developmental from degenerative aspects of the disorder.

描述：（逐字研究申请人的摘要）越来越多的证据 暗示精神分裂症是一种影响的神经行为疾病 大脑的额叶区域。一个相对忽视的，但在许多方面 理想的，对额 - 边缘系统的探测是嗅觉。嗅觉处理是 由边缘结构介导的，与 精神分裂症。嗅觉系统是独一无二的 在外围受体和感觉皮层之间，提供了最多 大脑与环境之间的直接联系。精神分裂症患者 具有明显的嗅觉缺陷。与相对静态的模式不同 但是，在疾病过程中看到的认知缺陷，嗅觉能力 似乎以线性方式下降，独立于正常衰老和性别 效果。但是，家庭研究也证明了明显的缺陷 精神分裂症的未受影响的一级亲戚中的嗅觉识别 概率。因此，似乎嗅觉大脑区域受到影响 通过遗传介导的发育以及神经退行性过程。 在这个项目中，我们将研究生理和解剖学 嗅觉功能障碍，纵向，患者，兄弟姐妹和 控件。我们将以先前的心理物理工作为基础，包括综合的 评估心理物理，心理生理学和体积测量的评估 嗅觉结构和功能。我们将研究40例精神分裂症患者， 40-否则健康的兄弟姐妹和40个无关的对照。生理数据 将使用独特且以前不可用的评估工具获取 单方面嗅觉事件相关电位（ERP），高密度 电极阵列以及电流源和偶极定位分析方法。 心理物理嗅觉测试数据和嗅觉的体积MRI测量 还将获得皮质区域以及嗅球和块状。全部 两年间隔后将重复测试，以评估任何差异 pat中的嗅觉能力下降，归因于其疾病 状态。这些嗅觉措施与临床，认知和 将研究情感症状。鉴于神经的相关性 底物，我们预计嗅觉完整性的全面评估 将阐明精神分裂症神经病理学的重要方面 可能特别有助于区分发展与退化 该疾病的方面。