NITRIC OXIDE AND CHOLINERGIC ACTIVITY IN SCHIZOPHRENIA
精神分裂症中的一氧化氮和胆碱能活性
基本信息
- 批准号:6126204
- 负责人:
- 金额:$ 16.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-12-15 至 2003-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (from applicant's abstract):
In schizophrenia, it has been hypothesized that sensory gating
abnormalities may be an underlying inherited deficit in the individuals
brain that alters its sensitivity to repeated stimuli, i.e., sensory
gating. Patients with schizophrenia are often heavy smokers and it is
currently believed that a short-lived beneficial therapeutic affect it
achieved through smoking on brain sensory processing. Although this
affect is involved with the nicotinic cholinergic effects of nicotine,
the finding of rapid desensitization which occurs to nicotinergic
receptors suggests that another more long-lived modulatory may be
involved with the therapeutic effects of nicotine in these patients. The
purpose of the application will be to investigate the hypotheses that
nicotinergic activation of hippocampal circuitry will lead to changes
in sensory gating that are mediated, in part, through increases in
extracellular levels of nitric oxide in discrete anatomical regions of
the hippocampus.
These studies will be conducted using a recently developed
microvoltammetric sensor that is very selective and sensitive for direct
spatially and temporally resolved measures of NO changes in the
extracellular space of the brain. These studies will investigate the
effects of cholinergic agnonists and antagonists of NO release in the
extracellular space of the rat hippocampus slices, anethesized rats and
free-moving animals. In addition, the potential interrelationships
between sensory gating and NO signaling will be investigated measuring
evolved potentials and NO release in the same animal. The studies should
contribute to a better understanding of AChergic mechanisms that may be
involved in NO signaling in the rat hippocampus, and potential role(s)
of NO in schizophrenia.
描述(来自申请人摘要):
在精神分裂症中,人们假设感觉门控
异常可能是个体潜在的遗传缺陷,
大脑改变其对重复刺激的敏感性,即,感官
门控精神分裂症患者通常是重度吸烟者,
目前认为,一个短暂的有益的治疗影响它,
通过吸烟对大脑感觉处理的影响来实现。虽然这
影响与尼古丁的烟碱胆碱能作用有关,
发现尼古丁能发生快速脱敏,
受体表明,另一个更长寿的调节可能是
与尼古丁对这些患者的治疗效果有关。的
应用程序的目的将是调查的假设,
海马电路的烟碱能激活将导致
在感觉门控中,
一氧化氮的细胞外水平在离散的解剖区域
海马体
这些研究将使用最近开发的
微伏安传感器是非常有选择性和敏感的直接
空间和时间分辨的措施,NO的变化,
大脑的细胞外空间。这些研究将调查
胆碱能激动剂和NO释放拮抗剂在脑内的作用
大鼠海马脑片细胞外间隙,麻醉大鼠,
自由移动的动物此外,潜在的相互关系
将研究感觉门控和NO信号之间的关系,
进化的潜力和NO释放在同一动物。研究应
有助于更好地理解可能是
参与大鼠海马中NO信号传导,以及潜在的作用
精神分裂症中的NO
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Greg A. Gerhardt其他文献
Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism.
通过可编程泵慢性脑内输送营养因子作为帕金森病的治疗方法。
- DOI:
- 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
R. Grondin;Zhiming Zhang;D. Elsberry;Greg A. Gerhardt;Don M. Gash - 通讯作者:
Don M. Gash
Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers
- DOI:
10.1007/s00213-006-0550-9 - 发表时间:
2006-10-10 - 期刊:
- 影响因子:3.300
- 作者:
B. Matthew Joyce;Paul E. A. Glaser;Greg A. Gerhardt - 通讯作者:
Greg A. Gerhardt
Multisite microelectrode arrays for measurements of multiple neurochemicals
用于测量多种神经化学物质的多位点微电极阵列
- DOI:
10.1109/iembs.2004.1404493 - 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
J. Burmeister;T. D. Coates;Greg A. Gerhardt - 通讯作者:
Greg A. Gerhardt
Costs of Implementing Quality in Research Practice.
在研究实践中实施质量的成本。
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
O. Meagan Littrell;Claudia Stoeger;H. Maier;H. Fuchs;M. Hrabě de Angelis;L. Cassis;Greg A. Gerhardt;Richard Grondin;V. Gailus - 通讯作者:
V. Gailus
Reply: GDNF poses troubling questions for doctors, drug maker.
答复:GDNF 给医生、制药商带来了令人不安的问题。
- DOI:
10.1002/ana.20880 - 发表时间:
2006 - 期刊:
- 影响因子:11.2
- 作者:
J. Slevin;Greg A. Gerhardt;Charles D. Smith;D. Gash;A. Young - 通讯作者:
A. Young
Greg A. Gerhardt的其他文献
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{{ truncateString('Greg A. Gerhardt', 18)}}的其他基金
Tonic and Phasic Glutamate Release from Psychomotor Stimulants
精神运动兴奋剂的强效和阶段性谷氨酸释放
- 批准号:
8446339 - 财政年份:2012
- 资助金额:
$ 16.35万 - 项目类别:
Tonic and Phasic Glutamate Release from Psychomotor Stimulants
精神运动兴奋剂的强效和阶段性谷氨酸释放
- 批准号:
8322257 - 财政年份:2012
- 资助金额:
$ 16.35万 - 项目类别:
NEUROCHEMICAL STUDIES OF THE AGING BASAL GANGLIA
老化基底神经节的神经化学研究
- 批准号:
7371007 - 财政年份:2007
- 资助金额:
$ 16.35万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
7252437 - 财政年份:2003
- 资助金额:
$ 16.35万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
6704868 - 财政年份:2003
- 资助金额:
$ 16.35万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
6807017 - 财政年份:2003
- 资助金额:
$ 16.35万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
7084604 - 财政年份:2003
- 资助金额:
$ 16.35万 - 项目类别:
Neurochem Chip: Methodology to Study Untethered Rats
Neurochem 芯片:研究不受束缚的大鼠的方法
- 批准号:
6920043 - 财政年份:2003
- 资助金额:
$ 16.35万 - 项目类别:
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