TESTING THE VALIDITY OF ADULT ATTENTION DEFICIT DISORDER

测试成人注意力缺陷障碍的有效性

• 批准号: 6185850
• 负责人: STEPHEN V FARAONE
• 金额: $ 44.69万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185850
• 关键词: adolescence (12-20); adult human (21+); alleles; attention deficit disorder; blood chemistry; clinical research; data collection; disease /disorder onset; dopamine receptor; dopamine transporter; family genetics; functional ability; genetic markers; genetic susceptibility; genotype; human genetic material tag; human subject; intelligence tests; interview; mental disorder diagnosis; mental health epidemiology; middle childhood (6-11); patient /disease registry; phenotype; siblings

DESCRIPTION (Adapted from applicant's abstract): Despite increasing media attention, adult Attention-deficit-hyperactivity disorder (ADHD) has not been systematically studied in large samples. As a result, there has been a debate in the field about the validity of ADHD in adults presenting at mental health clinics. To shed light on this debate, we propose to test hypothesis in one domain of adult ADHD that has received scant attention: its genetic epidemiology. As we review in the background section, there have been only two small pilot studies of the genetic epidemiology of ADHD. Such data are essential to validating the syndrome, creating developmentally appropriate diagnostic algorithms and laying the clinical foundation for genetic linkage studies. To fill this gap in the research literature, we will address the validity of adult ADHD from the genetic epidemiological perspective by testing the following hypothesis for the five main aims of our proposal: 1) Assessing the Familial Transmission of Adult ADHD; 2) Validating Adult ADHD with Molecular Genetic Data; 3) Assessing the Divergent Validity of Adult ADHD; 4) Using Family Study Data to Validate Diagnostic Models of Adult ADHD; AND 5) Creating a Resource for Future Follow-up and Molecular Genetic Studies of Adult ADHD. To acheive these aims, we will complete a double- blind family study of 140 ADHD families and 120 control families. We view our family study strategy as being a valuable investment for several reasons. A large double-blind study of adult ADHD has never been done before. Moreover, because consistent positive associations have been reported between childhood ADHD and two dopamine related genes, the collection of molecular genetic data will allow us to validate adult ADHD at the molecular level. Because we are collecting data about lifetime psychiatric diagnoses, we will be able to determine if other disorders can account for the familial transmission of ADHD or its molecular genetic associations. We will also be able to assess what age at onset criterion and what set of symptom thresholds should be used for the diagnosis of adult ADHD and will be able to define phenotypes and sample selection rules that will maximize the yield of future linkage studies. To maximize the scientific yield of this proposal, we will create a resource for future molecular genetic and follow-up studies of adult ADHD. We will set the stage for these studies by 1) providing a comprehensive baseline assessment for a follow-up study and 2) clarifying the nature of phenotypes and the sample sizes that will be needed for molecular genetic studies. Thus, if founded, we expect that the proposed work will lead to a program of research that can both clarify the nosological complexities of adult ADHD and clarify the nature of genes that are risk factors for the disorder.

描述（改编自申请人摘要）： 尽管越来越多的媒体关注，成人注意缺陷多动 注意力缺陷多动障碍（ADHD）尚未在大样本中进行系统研究。作为 因此，在该领域关于ADHD的有效性一直存在争议 在心理健康诊所就诊的成年人中。为了阐明这一点 辩论中，我们建议在一个成人ADHD领域测试假设， 很少受到关注：遗传流行病学。正如我们在 在背景部分，只有两个小的试点研究， ADHD的遗传流行病学这些数据对于验证 综合征，创造发育适当的诊断算法， 为遗传连锁研究奠定临床基础。填补这一 在研究文献的差距，我们将解决成人多动症的有效性 从遗传流行病学的角度，通过测试以下内容 假设我们的建议的五个主要目标：1）评估 成人ADHD的家庭传播; 2）用 分子遗传学数据; 3）评估成人ADHD的分歧效度; 4)利用家庭研究资料探讨成人注意缺陷多动障碍的诊断模式 和5）为未来的后续和分子遗传学创建资源 成人ADHD的研究为了实现这些目标，我们将完成一个双- 对140个ADHD家庭和120个对照家庭进行了盲法家庭研究。 我们认为我们的家庭学习策略是一项有价值的投资， 有几个原因。一项针对成人多动症的大型双盲研究从未被 以前做过。此外，由于一致的积极协会一直是 据报道，儿童多动症和两个多巴胺相关基因之间， 分子遗传数据的收集将使我们能够验证成人ADHD 在分子水平上。因为我们收集的是关于生命周期的数据 精神病诊断，我们将能够确定是否其他疾病可以 解释ADHD的家族传播或其分子遗传 协会.我们也将能够评估什么年龄在发病标准 以及应该使用哪组症状阈值来诊断 成人ADHD，并将能够定义表型和样本选择 规则，将最大限度地提高未来的联系研究的收益。最大化 这项建议的科学收益，我们将创造一个资源， 未来的分子遗传学和成人ADHD的后续研究。我们将设置 这些研究的阶段，1）提供一个全面的基线 2）明确后续研究的性质 表型和分子遗传学所需的样本量 问题研究因此，如果成立，我们预计拟议的工作将导致 一个既能阐明疾病分类学的复杂性 成人多动症的发病率，并澄清基因的性质是危险因素， 失调。