A NEW FUNCTIONAL EVALUATION TOOL FOR CANCER CARE

这个名为“癌症护理的新功能评估工具”的研究奖有两个目标。首先，研究目的是开发一种新的、患者管理的、多项选择的问卷，这将有助于评估绩效状况。其次，该奖项的职业发展部分将支持对候选人进行必要的技能教育，以构建和解释定性，从而增强他的量化技能和进行独立的、与结果有关的研究的能力。目前使用一到两个提供者评分量表来评估癌症患者的绩效状况：卡诺夫斯基绩效量表和东方合作肿瘤学小组绩效量表。虽然这些量表已经被广泛使用了很多年，但最近在量表开发方面的进展，以及最近评估这两个量表的研究都表明，这两个量表都没有达到通过构建良好的工具所能达到的表现水平。由于这些量表目前被用来决定治疗方法和临床试验的资格，这些量表的结构和性能问题可能会对癌症患者和癌症治疗研究产生重大影响。我们建议申请者在授权期内进行课堂作业、自学和规模发展的综合计划，我们希望这将产生一个改善身体机能的措施。该量表将通过四个步骤进行构建。1)通过访谈确定构成“功能”概念的领域。2)编写和测试反映这些领域的问题。3)领域和问题的信度、结构效度和预测效度的评估。4)通过对信度和效度检验结果的分析进行仪器组装，并对结果进行传播。

There are two objectives for this research award, entitled "A new functional evaluation tool for cancer care." First, the research aim is to develop a new, patient administered, multiple choice questionnaire that will be useful in the assessment of performance status. Second, the career development portion of the award will support the education of the candidate in the skills necessary to construct and interpret qualitative, thus augmenting his quantitative skills and his ability to perform independent, outcomes related research. The performance status of patients with cancer is currently assessed using one to two provider scored scales: the Karnofsky Performance Scale and the Eastern Cooperative Oncology Group performance scale. Although these scales have been seen wide use for many years, recent advances in scale development, and recent research evaluating these two scales have demonstrated that neither of these scales demonstrates the level of performance that could be achieved through a well constructed instrument. As these scale are currently used to make decisions about therapies and eligibility for clinical trials, structural and performance problems with the scales have the potential to substantially affect both patients with cancer, and research on cancer treatment. We propose for the applicant a combined program fo classwork, self study, and scale development over the grant period that we hope will yield an improved measure of physical function. The scale will be constructed through a four step process. 1) Identification of domains through interviews that make up the construct 'function'. 2) Writing and testing of questions that reflect these domains. 3) Assessment of reliability, construct validity, and predictive validity of the domains and the questions. 4) Instrument assembly through analysis of results of reliability and validity testing, followed by dissemination of results.