IMMUNE RESPONSES TO PNEUMOCOCCAL ANTIGENS IN CHILDREN

儿童对肺炎球菌抗原的免疫反应

• 批准号: 6190316
• 负责人: LISA J. KOBRYNSKI
• 金额: $ 11.49万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-07-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6190316
• 关键词: SCID mouse; Streptococcus pneumoniae; Streptococcus pneumoniae vaccine; T lymphocyte; adolescence (12-20); age difference; bacterial polysaccharides; bactericidal immunity; child (0-11); clinical research; developmental immunology; human subject; immunoglobulin G; serotyping

DESCRIPTION (Adapted from applicant's description): The objective of this proposal is to provide a period of mentored, multi-disciplinary training in clinical and laboratory research in pediatric immunology. CD 1 has recently been implicated in the antigen presentation of certain bacterial lipo-polysaccharides in a non-MHC dependent fashion. The applicant's data suggest that there is a role for CD1 restricted T cells in immune responses to pneumococcal polysaccharides and that a lack of these cells results in the inability to produce pneumococcal specific IgG. The proposed project will characterize these cells, delineate their role in polysaccharide antibody responses and ascertain whether patients in at-risk populations have alterations in this T cell subset. Identification of the precise role of these cells and the nature of the defect in susceptible hosts has the potential to lead to novel therapeutic regimes. This work has potentially broader applications in the immune responses to other polysaccharide antigens of common infectious agents. In addition, the applicant will pursue further training in study design and research methods, including didactic courses at the Rollins School of Public Health and the Graduate Division of Biological and Biomedical Sciences, at Emory.

描述（根据申请人的描述改编）：此目的 建议是提供一段时期的指导，多学科的培训 小儿免疫学的临床和实验室研究。 CD 1最近与某些人的抗原呈现有关 以非MHC依赖性的方式细菌脂糖糖。申请人的 数据表明，CD1限制的T细胞在免疫中起作用 对肺炎球菌多糖的反应，并且缺乏这些细胞 导致无法产生肺炎球菌特异性IgG。提议 项目将表征这些细胞，描绘它们在多糖中的作用 抗体反应并确定高危人群中的患者是否具有 该T细胞子集的变化。确定这些精确作用 细胞和易感宿主中缺陷的性质具有 导致新颖的治疗方案。这项工作可能更广泛 对其他多多糖抗原的免疫反应中的应用 常见的传染剂。 此外，申请人将在研究设计方面进行进一步的培训 研究方法，包括罗林斯公立学校的教学课程 健康和生物学科学研究生师 埃默里。