IMMUNE RESPONSES TO PNEUMOCOCCAL ANTIGENS IN CHILDREN

描述（改编自申请人的描述）：本申请的目的 建议提供一段时间的指导，多学科培训， 儿科免疫学的临床和实验室研究。 CD 1最近被牵连在抗原呈递某些 细菌脂多糖以非MHC依赖的方式。申请人的 数据表明，CD1限制性T细胞在免疫中发挥作用， 肺炎球菌多糖的反应，缺乏这些细胞， 导致不能产生肺炎球菌特异性IgG。拟议 该项目将描述这些细胞的特征，描述它们在多糖中的作用， 抗体反应，并确定高危人群中的患者是否有 在这个T细胞亚群的改变。确定这些机构的确切作用 细胞和易感宿主中缺陷的性质有可能 导致新治疗方案。这项工作具有潜在的更广泛 在对其它多糖抗原的免疫应答中的应用 常见的传染源 此外，申请人将继续接受研究设计方面的培训， 研究方法，包括罗林斯公共学院的教学课程 健康和生物与生物医学科学研究生部，在 埃默里

DESCRIPTION (Adapted from applicant's description): The objective of this proposal is to provide a period of mentored, multi-disciplinary training in clinical and laboratory research in pediatric immunology. CD 1 has recently been implicated in the antigen presentation of certain bacterial lipo-polysaccharides in a non-MHC dependent fashion. The applicant's data suggest that there is a role for CD1 restricted T cells in immune responses to pneumococcal polysaccharides and that a lack of these cells results in the inability to produce pneumococcal specific IgG. The proposed project will characterize these cells, delineate their role in polysaccharide antibody responses and ascertain whether patients in at-risk populations have alterations in this T cell subset. Identification of the precise role of these cells and the nature of the defect in susceptible hosts has the potential to lead to novel therapeutic regimes. This work has potentially broader applications in the immune responses to other polysaccharide antigens of common infectious agents. In addition, the applicant will pursue further training in study design and research methods, including didactic courses at the Rollins School of Public Health and the Graduate Division of Biological and Biomedical Sciences, at Emory.