IMMUNE RESPONSES TO PNEUMOCOCCAL ANTIGENS IN CHILDREN

儿童对肺炎球菌抗原的免疫反应

• 批准号: 6526560
• 负责人: LISA J. KOBRYNSKI
• 金额: $ 12.19万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6526560
• 关键词: SCID mouse; Streptococcus pneumoniae; Streptococcus pneumoniae vaccine; T lymphocyte; adolescence (12-20); age difference; bacterial polysaccharides; bactericidal immunity; child (0-11); clinical research; developmental immunology; human subject; immunoglobulin G; serotyping

DESCRIPTION (Adapted from applicant's description): The objective of this proposal is to provide a period of mentored, multi-disciplinary training in clinical and laboratory research in pediatric immunology. CD 1 has recently been implicated in the antigen presentation of certain bacterial lipo-polysaccharides in a non-MHC dependent fashion. The applicant's data suggest that there is a role for CD1 restricted T cells in immune responses to pneumococcal polysaccharides and that a lack of these cells results in the inability to produce pneumococcal specific IgG. The proposed project will characterize these cells, delineate their role in polysaccharide antibody responses and ascertain whether patients in at-risk populations have alterations in this T cell subset. Identification of the precise role of these cells and the nature of the defect in susceptible hosts has the potential to lead to novel therapeutic regimes. This work has potentially broader applications in the immune responses to other polysaccharide antigens of common infectious agents. In addition, the applicant will pursue further training in study design and research methods, including didactic courses at the Rollins School of Public Health and the Graduate Division of Biological and Biomedical Sciences, at Emory.

描述（改编自申请人的描述）：此目的 建议提供一段时间的指导性多学科培训 儿科免疫学的临床和实验室研究。 最近发现 CD 1 与某些抗原呈递有关 以非 MHC 依赖性方式产生细菌脂多糖。申请人的 数据表明 CD1 限制性 T 细胞在免疫中发挥作用 对肺炎球菌多糖的反应以及缺乏这些细胞 导致无法产生肺炎球菌特异性 IgG。拟议的 项目将描述这些细胞的特征，描述它们在多糖中的作用 抗体反应并确定高危人群中的患者是否有 该 T 细胞亚群的改变。确定这些的精确作用 细胞和易感宿主缺陷的性质有可能 导致新的治疗方案。这项工作可能具有更广泛的 在对其他多糖抗原的免疫应答中的应用 常见的传染源。 此外，申请人将继续接受研究设计和 研究方法，包括罗林斯公立学院的教学课程 健康与生物和生物医学科学研究生部，位于 埃默里。