BEHAVIORAL AND NEURAL CONCOMITANTS OF ETHANOL WITHDRAWAL
BEHAVIORAL AND NEURAL CONCOMITANTS OF ETHANOL WITHDRAWAL
批准号:
6163726
负责人:
DARIN J KNAPP
金额:
$9.26万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-03-01 至 2003-02-28
中文摘要
从慢性乙醇暴露中退出可伴有强烈的
英文摘要
Withdrawal from chronic ethanol exposure can be accompanied by an intense
anxiety---a component of the withdrawal syndrome for which the
neurochemical mechanisms and relevant neuroanatomical sites are unknown.
Recent data suggests that measurement of air puff-induced ultrasonic
vocalizations USVs in rats during withdrawal may be a particularly
relevant model for evaluating the increased anxiety observed during
withdrawal. Based upon this model, Specific Aim I of the present proposal
will evaluate the pharmacology of this behavioral response as well as
behavior in the elevated plus maze. Drugs to be evaluated during acute
withdrawal from chronic ethanol exposure are chosen based on their
effects on serotonergic receptor subtypes that have been demonstrated to
modulate anxiety. A benzodiazepine and an NMDA antagonist will serve as
positive controls for this experimental series. Specific Aim II will
identify brain sites where Fos-Like Immunoreactivity (Fos-LI) and c-Fos
mRNA are affected by drug treatments that block air puff induced
ultrasonic vocalizations and produce anxiolytic effects in the elevated
plus maze during ethanol withdrawal. This effort will identify specific
regions of brain activated during ethanol withdrawal and will allow for
systematic testing of specific sites for anti-anxiety effects of drugs.
Specific Aim III will determine the effects of drugs injected in specific
brain regions on ultrasonic vocalizations, plus maze behavior, and Fos-LI
and c-fos mRNA in ethanol withdrawal. This last aim will confirm which
regions expressing Fos-LI and c-fos mRNA may be relevant to the anti-
anxiety action of these drugs. This work will provide data that will
quantify the capacity of the serotonergic system to modulate the symptom
of withdrawal anxiety and will suggest brain regions and cellular
mechanisms responsible for ethanol withdrawal anxiety. Such efforts will
provide a better basis for understanding the neuroanatomical basis of
ethanol withdrawal anxiety as well as provide a framework for improved
pharmacotherapeutic strategies to treat this symptom in the future.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
MTA in vital pulp therapy- a pubmed based research review.
MTA 在活体牙髓治疗中的应用——基于出版的研究综述。
DOI:
--
发表时间:
2013
期刊:
Asian academic research journal of multidisciplinary
影响因子:
--
作者:
[Idnani,BarkhaJay, Choksi,Dipti]
通讯作者:
Choksi,Dipti
DOI:
--
发表时间:
1998-05
期刊:
The Journal of pharmacology and experimental therapeutics
影响因子:
--
作者:
[G. Duncan;D. Knapp;S. Carson;G. Breese]
通讯作者:
G. Duncan;D. Knapp;S. Carson;G. Breese
BEHAVIORAL AND NEURAL CONCOMITANTS OF ETHANOL WITHDRAWAL
-
批准号:2882024
-
项目类别:
-
资助金额:$8.99万
-
财政年份:1996
-
负责人:DARIN J KNAPP
-
依托单位:
BEHAVIORAL AND NEURAL CONCOMITANTS OF ETHANOL WITHDRAWAL
-
批准号:2667569
-
项目类别:
-
资助金额:$8.93万
-
财政年份:1996
-
负责人:DARIN J KNAPP
-
依托单位:
BEHAVIORAL AND NEURAL CONCOMITANTS OF ETHANOL WITHDRAWAL
-
批准号:2376048
-
项目类别:
-
资助金额:$8.68万
-
财政年份:1996
-
负责人:DARIN J KNAPP
-
依托单位:
BEHAVIORAL AND NEURAL CONCOMITANTS OF ETHANOL WITHDRAWAL
-
批准号:2042934
-
项目类别:
-
资助金额:$8.69万
-
财政年份:1996
-
负责人:DARIN J KNAPP
-
依托单位:
海外基金