MECHANISMS OF GENERATION OF GROWTH CONE CALCIUM WAVES
MECHANISMS OF GENERATION OF GROWTH CONE CALCIUM WAVES
批准号:
6187744
负责人:
NICHOLAS CANADAY SPITZER
金额:
$16.91万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-08 至 2002-08-31
中文摘要
描述(根据申请人摘要修改)
该项目的重点是自发升高的细胞内钙,
生长锥(钙波),调节神经突的延伸。的
神经突的生长以建立特定的神经元连接是一种
神经系统早期发育的重要方面。研究
提出了生长锥中钙波产生的机制,
两栖类脊髓神经元的培养,并有两个主要的具体目标。的
第一个目的是调查一个潜在的新的贡献,
钙渗漏途径与已知的钙转运蛋白结合,
钙波的产生。第二个目的是确定
以及细胞内钙储存在放大
生长锥中的细胞内钙,从而调节神经突
扩展名.细胞内钙离子的光学成像和离子记录
电流将用于实现这些目标。
英文摘要
DESCRIPTION (modified from applicant's abstract)
This project focuses on spontaneous elevations of intracellular calcium in
growth cones (calcium waves) that regulate extension of neurites. The
outgrowth of neurites to establish specific neuronal connections is an
important aspect of early development of the nervous system. The research
addresses the mechanisms of generation of calcium waves in growth cones of
amphibian spinal neurons in culture and has two major specific aims. The
first aim is to investigate the contributions of a potentially novel
calcium leak pathway in combination with known calcium transporters to the
generation of calcium waves. The second aim is to determine the identify
and roles of intracellular calcium stores in amplifying elevations of
intracellular calcium in growth cones and thereby regulating neurite
extension. Optical imaging of intracellular calcium and recording of ionic
currents will be used to address these aims.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1002/1097-4695(200008)44:2
发表时间:
2000-08-01
期刊:
JOURNAL OF NEUROBIOLOGY
影响因子:
--
作者:
[Gomez, TM, Spitzer, NC]
通讯作者:
Spitzer, NC
Determining Fundamental Properties of Neurotransmitter Switching in Adult Mammals
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批准号:10397554
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项目类别:
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资助金额:$55.3万
-
财政年份:2020
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Determining Fundamental Properties of Neurotransmitter Switching in Adult Mammals
-
批准号:10636784
-
项目类别:
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资助金额:$55.3万
-
财政年份:2020
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负责人:NICHOLAS CANADAY SPITZER
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依托单位:
Determining Fundamental Properties of Neurotransmitter Switching in Adult Mammals
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批准号:10152684
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项目类别:
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资助金额:$55.27万
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财政年份:2020
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负责人:NICHOLAS CANADAY SPITZER
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依托单位:
Drugs of abuse drive transmitter switching that causes drug-induced behavior
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批准号:9766809
-
项目类别:
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资助金额:$23.63万
-
财政年份:2019
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负责人:NICHOLAS CANADAY SPITZER
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依托单位:
Drugs of abuse drive transmitter switching that causes drug-induced behavior
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批准号:9982842
-
项目类别:
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资助金额:$19.69万
-
财政年份:2019
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Neurotransmitter Switching and Its Function in Hippocampal Plasticity
-
批准号:8806924
-
项目类别:
-
资助金额:$18.32万
-
财政年份:2014
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Genetic screens for analysis of Ca-dependent transmitter specification
-
批准号:7558888
-
项目类别:
-
资助金额:$28.04万
-
财政年份:2009
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Genetic screens for analysis of Ca-dependent transmitter specification
-
批准号:8063483
-
项目类别:
-
资助金额:$29.56万
-
财政年份:2009
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Genetic screens for analysis of Ca-dependent transmitter specification
-
批准号:7809570
-
项目类别:
-
资助金额:$28.29万
-
财政年份:2009
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Mechanisms of Calcium Transients in Neuronal Development
-
批准号:7098164
-
项目类别:
-
资助金额:$4.25万
-
财政年份:2006
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Mechanisms of Calcium Transients in Neuronal Development
-
批准号:7279474
-
项目类别:
-
资助金额:$30.56万
-
财政年份:2006
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Mechanisms of Calcium Transients in Neuronal Development
-
批准号:7673661
-
项目类别:
-
资助金额:$31.62万
-
财政年份:2006
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Mechanisms of Calcium Transients in Neuronal Development
-
批准号:7494588
-
项目类别:
-
资助金额:$30.63万
-
财政年份:2006
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Mechanisms of Calcium Transients in Neuronal Development
-
批准号:7232348
-
项目类别:
-
资助金额:$30.49万
-
财政年份:2006
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
Mechanisms of Calcium Transients in Neuronal Development
-
批准号:7120861
-
项目类别:
-
资助金额:$33.25万
-
财政年份:2005
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
MECHANISMS OF GENERATION OF GROWTH CONE CALCIUM WAVES
-
批准号:2892357
-
项目类别:
-
资助金额:$16.43万
-
财政年份:1998
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
MECHANISMS OF GENERATION OF GROWTH CONE CALCIUM WAVES
-
批准号:2697950
-
项目类别:
-
资助金额:$16.02万
-
财政年份:1998
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
FORMATION OF NEURAL PATHWAYS IN THE EMBRYO
-
批准号:2164877
-
项目类别:
-
资助金额:$16.25万
-
财政年份:1994
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
FORMATION OF NEURAL PATHWAYS IN THE EMBRYO
-
批准号:2164879
-
项目类别:
-
资助金额:$15.92万
-
财政年份:1994
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
INDUCTION AND COMPENTENCE IN THE RETINA
-
批准号:2164283
-
项目类别:
-
资助金额:$17.65万
-
财政年份:1994
-
负责人:NICHOLAS CANADAY SPITZER
-
依托单位:
海外基金