课题基金 / 基金详情

APOPTOSIS INDUCED BY TRAUMATIC BRAIN INJURY

APOPTOSIS INDUCED BY TRAUMATIC BRAIN INJURY
脑外伤引起的细胞凋亡
批准号:
6188005
负责人:
ALAN Ira FADEN
金额:
$23.77万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-05-15 至 2002-02-28

项目摘要

项目成果

ALAN Ira FADEN的其他基金

相关文献

中文摘要
翻译
描述(申请人摘要):中枢神经系统损伤后神经元细胞丢失
英文摘要
DESCRIPTION (Applicant's abstract): Neuronal cell loss following CNS injury results from apoptosis as well as necrosis. Although apoptosis has been demonstrated in brain after experimental traumatic brain injury (TBI), a critical role for apoptosis in post-traumatic tissue damage and related neurological deficits has yet to be established. Moreover, little is known about the molecular mechanisms involved in apoptosis after CNS injury. A number of studies have suggested a role for ICE or CPP32-like cysteine proteases (Called caspase-1 and caspase-3, respectively) in apoptosis of mammalian cells and the principal investigator has recently demonstrated that activation of caspase-3 is a control factor in apoptosis of cerebellar granular cells subjected to combined serum/K+ deprivation. Preliminary studies from our laboratory also indicate that activation of caspase-3 may be an important factor contributing to neuronal apoptosis following TBI in rats. The proposed studies are intended to address the following hypotheses: (1) TBI causes increased CPP32-like activity associated with neuronal apoptosis ; (2) Inhibition of caspase-3, but not ICE-like cysteine proteases (caspase-1), reduces post-traumatic apoptosis and associated neurological deficits. Specific Aims are: (1) To characterize the degree and temporal profile of apoptosis and to delineate the cell types involved in affected brain regions following lateral fluid percussion induced TBI in rats; (2) To determine tissue and cell-type specific changes in CPP32-like activity as a function of injury severity and time after trauma, as well as to correlate such changes with neuronal apoptosis; and (3) To examine the ability of selective caspase inhibitors to reduce post-traumatic caspase activity and related neuronal apoptosis, as well as associated neurological deficits after TBI, including determination of the therapeutic window for such neuroprotective actions.
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Bidirectional Brain-Gut interactions, chronic neuroinflammation and neurodegeneration after traumatic brain injury
  • 批准号:
    10684129
  • 项目类别:
  • 资助金额:
    $61.89万
  • 财政年份:
    2022
  • 负责人:
    ALAN Ira FADEN
  • 依托单位:
Bidirectional Brain-Gut interactions, chronic neuroinflammation and neurodegeneration after traumatic brain injury
  • 批准号:
    10517782
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2022
  • 负责人:
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  • 依托单位:
Mechanism of Inflammatory Related Brain Dysfunction after Spinal Cord Injury
  • 批准号:
    10597985
  • 项目类别:
  • 资助金额:
    $42.67万
  • 财政年份:
    2019
  • 负责人:
    ALAN Ira FADEN
  • 依托单位:
Reprogramming Microglial Epigenetic Pathways to Promote Cognitive Recovery after Brain Trauma.
  • 批准号:
    10381618
  • 项目类别:
  • 资助金额:
    $45.1万
  • 财政年份:
    2019
  • 负责人:
    ALAN Ira FADEN
  • 依托单位: