COGENT TO SUPPORT CLINICAL RESEARCH AT STANFORD

描述（改编自申请人摘要）：这是一个应用程序， 四年的CoGent资助，以支持由六名PI领导的7个NIMH资助的R 01， 斯坦福大学的精神病学和行为科学心理学系 大学R 01的重点是一些疾病-重度抑郁症， 没有精神病特征，强迫症，创伤后 应激障碍、脆性X和其他神经遗传综合征以及精神分裂症。 该CoGent将提高每个国家批准的研究的效率， 研究，扩大其范围，并允许重要的交叉研究 合作。它包括三个核心-招聘，统计和数据 管理和神经影像学。招聘中心将位于三个 地点（两个在帕洛阿尔托，一个在旧金山弗朗西斯科），以增加招聘 科目在旧金山弗朗西斯科， 少数民族科目的基本赠款。核心将促进主题 参与一项以上的研究。统计和数据管理核心 将协助开发可用于跨研究的方法， 纵向病程和结局（例如随机回归模型）， 随机临床试验（例如，受试者操作特征曲线 方法学），以及多个风险因素的相对贡献。的 神经影像核心将提供研究前暴露于模拟器，并提供 额外的扫描时间该CoGent的一个主要特点是功能磁共振成像的应用 在不同人群中进行研究的基本赠款。的几 研究已经使用功能磁共振成像来研究特定疾病中的情感和认知， 例如，在一个实施例中，精神分裂症，非精神病性和精神病性重性抑郁症，社会 恐惧症，脆性X等。CoGent将允许使用标准的功能磁共振成像 在这些病人群体中进行的实验， 跨项目-例如，幻觉型精神分裂症患者 精神抑郁症患者在两项研究中，使用功能磁共振成像将显着 通过探索治疗的具体效果来加强研究设计， 大脑功能

DESCRIPTION (Adapted from the Applicants Abstracts): This is an application for four years of CoGent funding to support 7 NIMH-funded R01's led by six PI's in the Departments of Psychiatry and Behavioral Sciences of Psychology at Stanford University. The R01's focus on a number of disorders - major depression with and without psychotic features, obsessive compulsive disorder, post-traumatic stress disorder, fragile X and other neurogenetic syndromes, and schizophrenia. This CoGent will increase the efficiency of the approved research of each of the studies, expand their scope, and allow for significant cross study collaborations. It consists of 3 cores - Recruitment, Statistics and Data Management, and Neuroimaging. The Recruitment Core will be located across three sites (two in Palo Alto and one in San Francisco) to increase recruitment of subjects. The San Francisco site will provide greater numbers of ethnic minority subjects for the Base Grants. The Core will facilitate subjects participating in more than one study. The Statistic and Data Management Core will assist in developing methods that can be used across studies for accessing longitudinal course and outcome (e.g. random regression models), response in randomized clinical trials (e.g. Reciever Operating Characteristics Curve Methodology), and the relative contributions of multiple risk factors. The Neuroimaging Core will offer prestudy exposure to a simulator and provide for additional scan time. A major feature of this CoGent is the application of fMRI across different populations being studied in the Base Grants. Several of the studies already use fMRI to study affect and cognition in specific disorders - e.g., schizophrenia, nonpsychotic and psychotic major depression, social phobia, fragile X, etc. The CoGent will permit utilization of standard fMRI experiments in these patient groups that will allow comparisons to be made across projects - e.g., hallucinating schizophrenic patients with hallucinating psychotic depressives. In two studies, the use of fMRI will significantly enhance the research design by exploring the specific effects of treatment on brain function.