Stanford Mood Disorders Center: Enhancing Core Clinical Research Resources

描述（由申请人提供）：这是响应RFA-恢复法案有限竞争的应用程序：支持新的教师招聘，以通过生物医学研究（P30）增强研究资源~为招聘初级教师临床科学家提供支持，以进一步发展心境障碍生物标志物领域的多学科计划。目前，我们正在寻找一位助理教授，从事整个生命周期中情绪障碍的功能性大脑成像生物标志物的研究。这位教员将在斯坦福大学医学院精神病学和行为科学系担任主要职务，并将成为斯坦福大学情绪障碍中心的成员。该提案的具体目标是：1。为助理教授，临床科学家提供启动资金，主要关注情绪障碍，特别强调功能性磁共振成像（f-MRI）研究，旨在阐明这些疾病的神经生物学。2.提供一个丰富的跨学科环境，以支持初级教师的持续研究职业发展。3.为跨学科的试点研究提供资金，对抑郁和/或焦虑患者和控制整个生命周期的f-MRI。一个例子的类型的跨学科的研究建议反映在最近的工作中指出，在处理和调节情绪的患者与抑郁症或广泛性焦虑症的潜在差异，并测试这些生物标志物的非共病和共病的患者与这些疾病的队列。在这组核心实验中确定的焦虑和抑郁相关生物标志物将应用于青少年和老年人试点研究。总之，这些研究可能有助于我们理解抑郁症在整个生命周期中的病理生理。 公共卫生相关性：情绪障碍非常常见，并与高发病率相关。涉及脑成像的跨学科研究可以帮助理解重性抑郁症的生物学基础，并有助于鉴别诊断和治疗开发。一个初级教师将得到支持，进行研究，可以帮助我们了解抑郁症在整个生命周期的发展。

DESCRIPTION (provided by applicant): This is an application in response to RFA-Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research (P30) ~ to provide support for recruitment of a junior faculty clinician scientist to work in and further develop a multidisciplinary program in the area of biomarkers of mood disorders. We are currently searching for an assistant professor to work on functional brain imaging biomarkers of mood disorders across the lifespan. The faculty member will have a primary appointment in the Department of Psychiatry and Behavioral Sciences at Stanford University Medical School and will be a member of the Stanford University Mood Disorders Center. The specific aims of the proposal are: 1. To provide start up funding for an assistant professor, clinician scientist with a primary interest in mood disorders with a particular emphasis on functional magnetic resonance imaging (f-MRI) studies aimed at elucidating the neurobiology of these disorders. 2. To provide an enriched interdisciplinary environment to support the continued research career development of junior faculty member(s). 3. To provide funding for interdisciplinary pilot studies on f-MRI of depressed and/or anxious patients and controls across the lifespan. An example of the type of indisciplinary research proposed is reflected in recent work pointing to potential differences in the processing and regulation of emotion in patients with major depression or generalized anxiety disorder, and to test these biomarkers on noncomorbid and comorbid cohorts of patients with these disorders. Anxiety- and depression-related biomarkers identified in this core set of experiments will then be applied in adolescent and geriatric pilot studies. Taken together, these studies may help our understanding of the pathophysiology of depression across the life span. PUBLIC HEALTH RELEVANCE: Mood disorders are extremely common and are associated with great morbidity. Interdisciplinary research involving brain imaging can help understand the biological bases of major depression and aid in differential diagnosis and treatment development. A junior faculty will be supported to conduct research that can help our understanding of the development of depression across the lifespan.