NIR TUNABLE LASER TISSUE WELDING

近红外可调激光组织焊接

• 批准号: 6126310
• 负责人: Robert Richard. Alfano
• 金额: $ 22.81万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6126310
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; infrared radiation; laser therapy; optics; portable biomedical equipment; tissue engineering

DESCRIPTION (Adapted from Applicant's Abstract): The applicants proposed a two-phase research program aimed at developing compact, portable near-infrared (NIR)-tunable solid-state lasers for tissue welding and developing better understanding of the laser tissue fusion mechanism. The specific aims of the proposed research will be: (1) development of NIR-tunable solid-state lasers to carry out laser tissue welding; and (2) study of the laser tissue welding using tunable lasers in animal skin and internal tissues to determine the effect of wavelength, average power, pulse duration, peak power, penetration depth, and tissue optical characteristics on the efficacy of the fusion process. The research will be focused on developing and testing compact, portable NIR tunable solid-state lasers based on well known laser crystals cr:forsterite, Cr:Ca2GeO4 and a new promising crystal Cr:LiInGeO4 filling the void around 1300 nm, for tissue welding developing better understanding of the laser tissue fusion mechanism. The laser-development effort will provide compact and reliable lasers with optimal characteristics for clinical tissue welding applications.

描述（改编自申请人的摘要）：申请人提出了一种 两个阶段的研究计划，旨在开发紧凑，便携式近红外 （近红外）可调谐固体激光器用于组织焊接和发展更好 了解激光组织融合机制。的具体目标 拟议的研究将是：（1）发展近红外可调谐固态激光器， 进行激光组织焊接;（2）研究了激光组织焊接技术， 可调谐激光器在动物皮肤和内部组织，以确定 波长、平均功率、脉冲持续时间、峰值功率、穿透深度，以及 组织光学特性对融合过程的功效的影响。的 研究的重点将是开发和测试紧凑、便携式近红外 基于公知的激光晶体Cr：镁橄榄石的可调谐固态激光器， Cr：Ca_2GeO_4和一种新的有前途的晶体Cr：LiInGeO_4填充了1300 ℃左右的空隙 nm，用于组织焊接，以更好地理解激光组织 聚变机制激光开发工作将提供紧凑且 具有最佳临床组织焊接特性的可靠激光器 应用.