BRAIN MONOAMINES AND CONDITIONED BEHAVIOR
BRAIN MONOAMINES AND CONDITIONED BEHAVIOR
批准号:
6185741
负责人:
LEWIS S SEIDEN
金额:
$32.93万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1977
资助国家:
美国
项目状态:
已结题
起止时间:
1977-12-15 至 2002-07-31
中文摘要
描述(改编自申请人摘要):
英文摘要
DESCRIPTION (Adapted From The Applicant's Abstract):
Unipolar depression is the most common mental health problem today. The
differential reinforcement of low rate 72-second schedule of reinforcement (DRL
72-s schedule) is a sensitive and selective behavioral screen for
antidepressant (AD) drugs. Drugs such as serotonin-1A (5HT1A) receptor agonists
and 5HT2A receptor antagonists, as well as selective 5HT reuptake inhibitors
(SSRIs), have antidepressant-like profiles on the DRL 72-s task. Rats
selectively-bred for increased sensitivity to the hypothermic effects of the
5HT1A receptor agonist 8-OH-DPAT, high DPAT sensitive (HDS) rats, differ from
their selectively-bred counterparts, low DPAT sensitive (LDS) rats, in baseline
performance and in response to 5HT- specific ADs on the DRL. The
selectively-bred rats also have different immobility times in the forced swim
test (FST), another behavioral task that has been previously shown to be
sensitive to ADs. The overall objective of this proposal is to more fully
understand 5HT mechanisms underlying depression and the action of ADs by making
use of the HDS and LDS lines of rats. The aim of the first set of studies is to
compare and examine the effects of ADs from several drug classes on DRL and FST
behavior; additionally, we propose to examine the effects of whole-brain and
local 5HT depletions in these two behavioral paradigms, as well as investigate
how the action of ADs is modified by 5HT depletions. The aim of the second set
of experiments is to determine if differences exist in pre- and postsynaptic
receptor function between the HDS and LDS rats using in vitro microdialysis,
radioligand binding for 5HT1A and 5HT2A/C receptors, and the 5HT transporter,
and second messenger assays. Taken together, these studies will determine
whether these behavioral differences are regulated by the 5HT system, and will
determine which components of the serotonergic system are responsible for the
functional differences between the HDS and LDS lines of rats. The results of
these studies will help us further understand the etiology and substrates
underlying depression.
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NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RESEARCH
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批准号:2013076
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项目类别:
-
资助金额:$30.75万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RESEARCH
-
批准号:6378519
-
项目类别:
-
资助金额:$45.32万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RES
-
批准号:2119622
-
项目类别:
-
资助金额:$30.13万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RES
-
批准号:2119625
-
项目类别:
-
资助金额:$31.42万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RESEARCH
-
批准号:6174655
-
项目类别:
-
资助金额:$39.06万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RESEARCH
-
批准号:2700854
-
项目类别:
-
资助金额:$31.29万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RES
-
批准号:2119623
-
项目类别:
-
资助金额:$30.94万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOLGY TRG FOR DRUG ABUSE RESEARCH
-
批准号:3534035
-
项目类别:
-
资助金额:$18.02万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RESEARCH
-
批准号:2897852
-
项目类别:
-
资助金额:$36.13万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
NEUROPSYCHOPHARMACOLOGY TRAINING FOR DRUG ABUSE RES
-
批准号:2119624
-
项目类别:
-
资助金额:$28.53万
-
财政年份:1991
-
负责人:LEWIS S SEIDEN
-
依托单位:
BRAIN MONOAMINES, DRUGS AND CONDITIONED BEHAVIOR
-
批准号:2241788
-
项目类别:
-
资助金额:$10.08万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
BRAIN MONOAMINES AND CONDITIONED BEHAVIOR
-
批准号:2242735
-
项目类别:
-
资助金额:$25.1万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
BRAIN MONOAMINES, DRUGS AND CONDITIONED BEHAVIOR
-
批准号:2241789
-
项目类别:
-
资助金额:$9.28万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
RESEARCH CENTER: STUDIES OF DRUG DEPENDENCE & ABUSE
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批准号:3105312
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项目类别:
-
资助金额:$89.9万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
RESEARCH CENTER: STUDIES OF DRUG DEPENDENCE & ABUSE
-
批准号:3105304
-
项目类别:
-
资助金额:$79.97万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
RESEARCH CENTER: STUDIES OF DRUG DEPENDENCE AND ABUSE
-
批准号:3105310
-
项目类别:
-
资助金额:$68.66万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
BRAIN MONOAMINES AND CONDITIONED BEHAVIOR
-
批准号:2609429
-
项目类别:
-
资助金额:$32.65万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
BRAIN MONOAMINES, DRUGS AND CONDITIONED BEHAVIOR
-
批准号:3075983
-
项目类别:
-
资助金额:$9.54万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
BRAIN MONOAMINES AND CONDITIONED BEHAVIOR
-
批准号:3486300
-
项目类别:
-
资助金额:$21.22万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
BRAIN MONOAMINES AND CONDITIONED BEHAVIOR
-
批准号:2242734
-
项目类别:
-
资助金额:$25.21万
-
财政年份:1977
-
负责人:LEWIS S SEIDEN
-
依托单位:
海外基金