CORE--PATIENT ACCESS, DATA MANAGEMENT AND TISSUE CULTURE

治疗相关性白血病是一种晚期并发症， 细胞毒性药物和/或辐射。这是一个独特的临床病理学 以及通常致命的细胞遗传学综合征。 的一个特殊 该计划的特点是，四个单独的项目是 完全依赖于病人的材料，因为大多数问题 需要解决的问题来自个体患者反应的性质。 也就是说，为什么有些患者会发展为继发性白血病，而另一些患者 什么都没有？ 除了患者入组、病历审查、标本采集 和数据采集，我们再次建议将原始 对数据库协调、统计分析和 计算 此外，我们建议扩大我们对遗传学的研究， 通过建立一个登记系统， 原发性和继发性白血病家族，以确定家族性 聚合。 Patient Access核心具有标本采集的双重任务 数据管理和分析。 这些功能对于 成功完成拟议的调查， 支持并将来自不同领域的成果联系在一起， laboratories. 通过这种方式，可以传播对数据的中期分析 及时在项目研究者中，以及独特的患者资源 可以以最有成效的方式分享。 为了提供对患者材料的有序访问， 记录，我们建议继续我们的核心组成部分，以管理这些 像过去10年一样发挥作用。 特定临床要求 材料（血液或骨髓细胞，肿瘤组织，来自口腔拭子的DNA， 或来自特定患者或家庭成员的细胞系）将被定向 每个项目PI到核心。 采集后，临床标本 将被登录并运送到处理和交付到 个别项目。 数据表格将保存在安全的文件柜中， 研究数据将保存在密码下的电子文件中 安全

Therapy-related leukemia is a late complication of treatment with cytotoxic drugs and/or irradiation. It is a distinctive clinicopathological and cytogenetic syndrome that is usually fatal. One of the special features of this program is that the four individual projects are absolutely dependent upon patient material, since most of the questions to be addressed arise from the nature of individual patient responses. That is, why do some patients develop secondary leukemia and others not? In addition to patient enrollment, chart review, specimen collection and data acquisition, we propose again to incorporate within the original Core formal support for database coordination, statistical analysis, and computation. In addition, we propose to expand our studies on genetic susceptibility for the development of leukemia by establishing a registry of primary and secondary leukemia families in order to ascertain familial aggregations. The Patient Access core has the dual missions of specimen acquisition and data management and analysis. These functions are critical to the successful completion of the proposed investigations and necessary to support and link together the results that will come from the various laboratories. In this way, interim analyses of data may be disseminated promptly among the project investigators, and unique patient resources may be shared in the most productive manner. In order to provide an orderly access to patient material and to maintain records, we propose to continue our Core component to manage these functions as it has for the past 10 years. Requests for specific clinical materials (blood or marrow cells, tumor tissues, DNA from buccal swabs, or cell lines from specific patients or family members) will be directed by each project PI to the Core. After collection, the clinical specimens will be logged in and transported for processing and delivery to the individual projects. Data forms will be kept in secure file cabinets, and research data will be maintained in electronic files under password security.