CORE--ANIMAL

动物护理中心将提供动物护理、动物收容所和 SCID小鼠及异种移植瘤的制备及实验研究这个 核心活动还负责协调行政管理， 动物护理活动的监管报告和财务管理。 由于SCID小鼠是免疫抑制的，并且含有人类肿瘤， 需要专门的护理。所有的动物手术都需要无菌 技术和操控者需要专门的培训。 动物保护核心人员订购SCID小鼠，维护日常记录 所有的肿瘤和动物，将移植的人类黑色素瘤细胞注射到 受体异种移植，监测原发肿瘤异种移植瘤的生长 F1和F2代，根据治疗需要移植F2肿瘤 并为-95摄氏度的储存准备异种移植物。《动物核心》 工作人员负责准备所有的法规记录 动物资源和国际动物保护委员会每日例会 为动物提供维护、饲养和设施卫生服务 作为动物资源部购买的服务。动物是 最初被隔离在中心动物设施中，肿瘤 在中心动物设施进行生物安全接种和移植 2级条件下，然后在无菌条件下转移到 用于监测肿瘤生长的实验动物设施 项目1、2、3或4中的治疗。 丹尼斯·B·利珀为核心主任，朱迪思·A·戴沃为研究所所长 兽医，是联席主任。利珀博士将指导和监督所有 行动。戴沃博士将在监测所有 行动，审查所有程序，确保所有人的健康和护理 并帮助改善和提升动物护理和外科手术 程序。戴维奥博士的专长是照顾实验动物。两者都有 Daviau博士和Leeper博士拥有丰富的动物监管经验 护理，包括成群的SCID小鼠。利珀博士是 爱护动物中心提供移植的黑色素瘤细胞 为项目1、2和3进行异种移植，并提供所有动物和肿瘤 项目4和宾夕法尼亚大学的分包合同。 该实验动物设施已获得美国航空航天局的批准。

The Animal Care Core will provide animal care, animal housing and preparation of SCID mice and xenograft tumors for experimentation. The core activity is also responsible for coordinating the administration, regulatory reporting and fiscal management of animal care activities. Since SCID mice are immune suppressed and contain human tumors, specialized care is required. All animal procedures require sterile technique and handlers require specialized training. The Animal Care Core staff orders SCID mice, maintain the daily records on all of the tumors and animals, inject explanted human melanoma cells into recipient xenografts, monitor the growth of primary tumor xenografts in the F1 and F2 generations, transplant F2 tumors as required for treatment and prepare xenografts for -95 degrees Celsius storage. The Animal Core staff is responsible for preparation of all regulatory records for the Department of Animal Resources and the I.A.C.U.C. The routine daily maintenance, husbandry and facility hygiene for the animals are provided as a purchased service by the Department of Animal Resources. Animals are initially housed in isolation in the Central Animal Facility, tumors inoculated and transplanted in the Central Animal Facility under Biosafety Level 2 conditions and then transferred under sterile conditions to the laboratory animal facility for monitoring tumor growth for subsequent treatment in Projects 1, 2, 3 or 4. Dennis B. Leeper is the Core Director and Judith A. Daviau, Institute Veterinarian, is the Co-Director. Dr. Leeper will direct and oversee all operations. Dr. Daviau will have a critical role in monitoring all operations, reviewing all procedures, seeing to the health and care of all animals and helping improve and upgrade animal care and surgical procedures. Dr. Daviau's specialty is the care of laboratory animals. Both Dr. Daviau and Dr. Leeper have extensive experience supervising animal care, including colonies of SCID mice. Dr. Leeper is a member of the I.A.C.U.C. The Animal Care Core provides explanted melanoma cells from xenografts for Projects 1,2 and 3 and provides all the animals and tumors for Project 4 and the Subcontract with the University of Pennsylvania. The laboratory animal facility is A.A.A.L.A.C. approved.