CORE--CELL AND TISSUE BANK

华盛顿大学ADRC核心E：细胞和组织库是历史上最古老的阿尔茨海默病和其他神经退行性疾病，家族性和散发性的储存库。该中心保存了低温保存的淋巴母细胞样细胞系、淋巴细胞、成纤维细胞、血浆，以及活检和尸检皮肤标本，用于分子和生化实验和分析。核心的目标是：1。获取、扩增和冷冻保存来自家族性和散发性阿尔茨海默病（AD）患者的各种细胞类型和冷冻血浆。我们还将获取和保存其他退行性疾病患者的细胞、组织和/或细胞系，以及适当的对照。我们将储存由利用转基因或敲除ad相关基因/蛋白的细胞和动物模型产生的细胞系。2. 应ADRC研究人员的要求，并经ADRC执行委员会同意，通过材料转移机制将储存的细胞系或菌株分发给华盛顿大学和其他机构的研究人员。

The University of Washington ADRC Core E: Cell and Tissue Bank is historically the oldest repository for Alzheimer Disease and other neurodegenerative disorders, familial and sporadic. The Core maintains cryogenically preserved lymphoblastoid cell lines, lymphocytes, fibroblasts, plasma, as well as biopsy and autopsy skin specimens for molecular and biochemical experiments and assays. The aims of the Core are: 1. Acquire, expand and cryopreserve various cell types and to freeze plasma derived from patients with familial and sporadic Alzheimer's disease (AD). We will also acquire and preserve cells, tissues, and/or cell lines from patients with other degenerative disorders, and appropriate controls. We will bank cell lines generated from cell and animal models that utilize transgenes or knockouts of AD-associated genes/proteins. 2. Distribute stored cell lines or strains upon request by investigators with in the ADRC and, upon approval in concurrence with the ADRC Executive committee, to investigators at the University of Washington and other institutions via a Materials Transfer mechanism.