CORE--COLORECTAL AND PANCREATIC CANCER PATIENT REGISTRY

1973年，一项对遗传性乳腺癌患者的登记和临床研究， 息肉病和结直肠癌综合征是在约翰 霍普金斯医院。1984年，肠道肿瘤工作组成立， 研究结直肠肿瘤的生物学，并扩大登记 功能协调发展的 书记官处由计算机化的Dbase III数据库维持 包括：1）家庭史和食物频率问卷716 评估结直肠肿瘤的患者，2）2120个有 根据其家族史入组登记研究，包括 遗传性结直肠癌综合征家系，家族聚集性 结直肠癌和早期结直肠癌。的核心部分 SPORE现已扩大到包括胰腺癌患者。 目前，结肠直肠癌和胰腺癌的核心收集家庭 受影响和风险个体的病史、饮食数据， 调查家庭和环境因素在 结肠直肠癌和胰腺癌的分子遗传学改变。

In 1973, a registry and clinical study of patients with hereditary polyposis and colorectal cancer syndromes was initiated at The Johns Hopkins Hospital. In 1984, the Bowel Tumor Working Group was formed to study the biology of colorectal tumors and to expand the Registry functions. The Registry is maintained in a computerized Dbase III database and includes: 1) family histories and food frequency questionnaires of 716 patients evaluated for colorectal neoplasia and, 2) 2120 families who have been enrolled in the Registry based on their family history, including families with hereditary colorectal cancer syndromes, familial aggregation of colorectal cancer and early onset of colorectal cancer. The Core for the SPORE has now been expanded to included pancreatic cancer patients. Presently, the CORE for Colorectal and Pancreatic Cancer collects family history, dietary data from affected and at-risk individuals to support investigations of the role of familial and environmental factors in the molecular genetic alterations in both colorectal and pancreatic carcinoma.