CORE--COLORECTAL AND PANCREATIC CANCER PATIENT REGISTRY

核心——结直肠癌和胰腺癌患者登记

• 批准号: 6300469
• 负责人: FRANCIS M GIARDIELLO
• 金额: $ 21.92万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-18 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6300469
• 关键词: biomedical facility; cancer registry /resource; colorectal neoplasms; disease /disorder onset; human data; pancreas neoplasms

In 1973, a registry and clinical study of patients with hereditary polyposis and colorectal cancer syndromes was initiated at The Johns Hopkins Hospital. In 1984, the Bowel Tumor Working Group was formed to study the biology of colorectal tumors and to expand the Registry functions. The Registry is maintained in a computerized Dbase III database and includes: 1) family histories and food frequency questionnaires of 716 patients evaluated for colorectal neoplasia and, 2) 2120 families who have been enrolled in the Registry based on their family history, including families with hereditary colorectal cancer syndromes, familial aggregation of colorectal cancer and early onset of colorectal cancer. The Core for the SPORE has now been expanded to included pancreatic cancer patients. Presently, the CORE for Colorectal and Pancreatic Cancer collects family history, dietary data from affected and at-risk individuals to support investigations of the role of familial and environmental factors in the molecular genetic alterations in both colorectal and pancreatic carcinoma.

1973年，一项针对遗传性遗传病患者的登记和临床研究 息肉病和结直肠癌综合征是在约翰斯发起的 霍普金斯医院。 1984 年，肠肿瘤工作组成立 研究结直肠肿瘤的生物学并扩大登记范围 功能。 注册表维护在计算机化的 Dbase III 数据库中 包括：1）716人的家族史和食物频率调查问卷 接受结直肠肿瘤评估的患者，2) 2120 个患有结直肠肿瘤的家庭 根据家族史在登记处登记，包括 患有遗传性结直肠癌综合征的家庭，家族聚集 结直肠癌的发生和结直肠癌的早期发病。核心为 SPORE 现已扩展到包括胰腺癌患者。 目前，结直肠癌和胰腺癌的 CORE 正在收集家庭成员 受影响和高危个体的病史、饮食数据以支持 家庭和环境因素在影响中的作用的调查 结直肠癌和胰腺癌的分子遗传改变。