ANATOMY OF NEUROENDOCRINE PEPTIDE PATHWAYS IN BRAIN
大脑神经内分泌肽通路的解剖
基本信息
- 批准号:6105166
- 负责人:
- 金额:$ 21.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-06-01 至 2000-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Description: (Taken directly from the application). Corticotropin-
driving pituitary-adrenal responses to stress. CRF is also widely
pituitary-adrenal responses to stress. CRF is also widely expressed in
complementary autonomic and behavioral mechanisms that are commonly invoked
autonomic and behavioral mechanisms that are commonly invoked following
of a functional CRF receptor (CRF-R) provides a critical tool with which to
a functional CRF receptor (CRF-R) provides a critical tool with which
distribution in pituitary is fully compatible with the major neuroendocrine
distribution in pituitary is fully compatible with the major
containing projections, particularly in regions implicated as stress-
of CRF-containing projections particularly in regions implicated as
identifying, and providing a functional anatomical context, for areas in
aimed at identifying and providing a functional anatomical context for
alternative hypotheses as to how discrepancies may be reconciled in regions
to pursue alternative hypotheses as to how discrepancies may be
and electron microscopic level to characterize the cellular and subcellular
will be used at the light and electron microscopic level to characterize
corticotropin in pituitary. Dual staining approaches will assess
those of CRF in brain and of corticotropin in pituitary. Dual staining
apposed to postsynaptic membrane specializations with which CRF-R-ir is
terminals may be synaptically apposed to postsynaptic membrane
of mRNA and/or protein expression will be employed to determine first how
regions of interest. Various in situ assays of mRNA and/or protein
environment, the major factors modulating CRF expression within and beyond
stress and perturbations in the corticosteroid environment the major
processed in CRF target cells in brain and pituitary that do and do not
hypothalamus. The manner in which CRF-R is sequestered and processed in
will be explored at the light and electron microscopic levels under basal
another high-affinity CRF-binding moiety the CRF- binding protein will
hybridization histochemical approaches like those just described to
challenged conditions. Finally we will employ immuno- and hybridization
accommodated by novel ligands for the CRF-R and/or the existence of
major areas of apparent ligand-receptor mismatch may be accommodated by
processing variants or subtypes. Alterations in titers and/or
extrahypothalamic CRF can lead to Cushingoid or Addisonian symptoms,
to Cushingoid or Addisonian symptoms modified susceptibility to immune
the etiology of affective disorders such as anorexia nervosa and major
disorders such as anorexia nervosa and major depression. Collectively
neuroendocrine and neurobiological contexts for signaling by CRF at
neurobiological contexts for signaling by CRF at multiple levels of
stress-related neuronal and neuroendocrine systems.
描述:(直接从应用程序中获取)。促肾上腺皮质激素-
刺激垂体肾上腺对压力的反应 CRF还广泛
垂体肾上腺对压力的反应CRF也广泛表达于
互补的自主和行为机制,
自动和行为机制,通常在以下情况下调用
功能性CRF受体(CRF-R)的表达提供了一个关键工具,
功能性CRF受体(CRF-R)提供了一种关键工具,
垂体中的分布与主要神经内分泌完全一致
垂体中的分布与主要的
包含突出物,特别是在涉及应力的区域中,
包括通用报告格式的预测,特别是在涉及
识别和提供功能解剖学背景,
旨在识别和提供功能解剖背景,
关于如何调和各区域差异的备选假设
寻求替代假设,以了解差异如何可能是
和电子显微镜水平来表征细胞和亚细胞
将在光学和电子显微镜水平上用于表征
垂体促肾上腺皮质激素。 双重染色方法将评估
脑内CRF和垂体促肾上腺皮质激素的变化。双重染色
与突触后膜特化并列,CRF-R-ir是
终末可与突触后膜突触并列
mRNA和/或蛋白质表达将被用来确定首先如何
感兴趣的区域。mRNA和/或蛋白质的各种原位测定
环境,调节CRF表达的主要因素内外
皮质类固醇环境中的压力和扰动主要
在脑和垂体中的CRF靶细胞中进行处理,
下丘脑CRF-R被隔离和处理的方式
将探讨在光和电子显微镜水平下的基础
另一种高亲和力CRF结合部分CRF结合蛋白将
杂交组织化学方法,如刚刚描述的那些,
挑战条件。最后,我们将采用免疫和杂交
通过CRF-R的新配体和/或CRF-R的存在来调节,
明显配体-受体错配的主要区域可通过
处理变体或子类型。滴度变化和/或
下丘脑外CRF可导致库欣样或艾迪生症状,
对库欣样或艾迪生症状的敏感性改变,
情感障碍如神经性厌食症和重度抑郁症
神经性厌食症和严重抑郁症等疾病。集体
CRF信号传导的神经内分泌和神经生物学背景.
CRF在多个水平上的信号传导的神经生物学背景
压力相关神经和神经内分泌系统。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul E. Sawchenko其他文献
Paul E. Sawchenko的其他文献
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{{ truncateString('Paul E. Sawchenko', 18)}}的其他基金
Anatomy of neuroendocrine peptide pathways in brain
大脑神经内分泌肽通路的解剖
- 批准号:
7429660 - 财政年份:2007
- 资助金额:
$ 21.48万 - 项目类别:
Anatomy of neuroendocrine peptide pathways in brain
大脑神经内分泌肽通路的解剖
- 批准号:
6956169 - 财政年份:2005
- 资助金额:
$ 21.48万 - 项目类别:
Mechanisms of Emotional Stress Effects on Hypothalamus
情绪压力对下丘脑影响的机制
- 批准号:
7077629 - 财政年份:2004
- 资助金额:
$ 21.48万 - 项目类别:
Mechanisms of Emotional Stress Effects on Hypothalamus
情绪压力对下丘脑影响的机制
- 批准号:
6809898 - 财政年份:2004
- 资助金额:
$ 21.48万 - 项目类别:
Mechanisms of Emotional Stress Effects on Hypothalamus
情绪压力对下丘脑影响的机制
- 批准号:
6895261 - 财政年份:2004
- 资助金额:
$ 21.48万 - 项目类别:
Mechanisms of Emotional Stress Effects on Hypothalamus
情绪压力对下丘脑影响的机制
- 批准号:
7261241 - 财政年份:2004
- 资助金额:
$ 21.48万 - 项目类别:
ANATOMY OF NEUROENDOCRINE PEPTIDE PATHWAYS IN BRAIN
大脑神经内分泌肽通路的解剖
- 批准号:
6594593 - 财政年份:2002
- 资助金额:
$ 21.48万 - 项目类别:
ANATOMY OF NEUROENDOCRINE PEPTIDE PATHWAYS IN BRAIN
大脑神经内分泌肽通路的解剖
- 批准号:
6588831 - 财政年份:2001
- 资助金额:
$ 21.48万 - 项目类别:
ANATOMY OF NEUROENDOCRINE PEPTIDE PATHWAYS IN BRAIN
大脑神经内分泌肽通路的解剖
- 批准号:
6468425 - 财政年份:2001
- 资助金额:
$ 21.48万 - 项目类别:
ANATOMY OF NEUROENDOCRINE PEPTIDE PATHWAYS IN BRAIN
大脑神经内分泌肽通路的解剖
- 批准号:
6564212 - 财政年份:2001
- 资助金额:
$ 21.48万 - 项目类别:
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