SALIVARY ARGININE/LYSINE/PEPTIDES AND CARIES EXPERIENCE
SALIVARY ARGININE/LYSINE/PEPTIDES AND CARIES EXPERIENCE
批准号:
6104905
负责人:
Lawrence A. Tabak
金额:
$16.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-07-01 至 2001-02-28
中文摘要
无龋齿和龋齿之间观察到的最一致的差异是
易受影响的受试者涉及斑块 pH 值的调节;无龋齿
个人更有效地中和牙菌斑酸。我们假设
这种差异与游离二元氨基酸水平升高有关
以及无龋齿者唾液中含有精氨酸/赖氨酸的肽
人。
我们将首先定量单个低分子量的水平
从成熟的无龋和龋齿收集的腮腺唾液中的肽
易感成年人(等于或超过 50 岁)。唾液肽
观察到与龋齿经历相关的
其特点是能够缓冲斑块液体并产生
由口腔微生物代谢产生氨。我们还将提出
与龋齿相关的唾液肽抗体
开发免疫测定法来定量这些的经验
肽。然后我们将确定一组中这些肽的水平
将接受为期四年的纵向检查的儿童人数;在每个
检查时,龋齿状况(即无龋齿或易龋齿)将
确定腮腺唾液肽和游离氨基酸的定量。
鉴定与菌斑 pH 相关的唾液因子
监管将增强我们对宿主对牙科的抵抗力的理解
龋齿。
英文摘要
The most consistent difference observed between caries-free and caries-
susceptible subjects relates to regulation of plaque pH; caries free
individuals neutralize plaque acid more effectively. We hypothesize that
this difference is related to elevated levels of free dibasic amino acids
and arginine/lysine-containing peptides in the saliva of caries-free
persons.
We will first quantitate levels of individual low molecular weight
peptides in parotid saliva collected from mature caries-free and caries-
susceptible adults (equal to or more than 50 yrs.). Salivary peptides
which are observed to be associated with caries experience will be
characterized for their ability to buffer plaque fluid and to yield
ammonia when metabolized by oral microorganisms. We will also raise
antibodies to the salivary peptides which are associated with caries
experience for the purpose of developing immunoassays to quantitate these
peptides. We will then determine the levels of these peptides in a group
of children who will be examined longitudinally for four years; at each
exam, caries status (i.e. caries-free or caries-susceptible) will be
determined and parotid salivary peptides and free amino adds quantitated.
The identification of salivary factors which are involved in plaque pH
regulation will enhance our understanding of host resistance to dental
caries.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Genomic/proteomic analysis of human salivary glands
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批准号:6349648
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项目类别:
-
资助金额:$22.18万
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财政年份:2000
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负责人:Lawrence A. Tabak
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依托单位:
IOCB CONFERENCE ON SALIVA IN HEALTH AND DISEASE
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批准号:6124717
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项目类别:
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资助金额:$1.0万
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财政年份:2000
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负责人:Lawrence A. Tabak
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依托单位:
SALIVARY ARGININE/LYSINE/PEPTIDES AND CARIES EXPERIENCE
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批准号:6270345
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项目类别:
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资助金额:$15.78万
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财政年份:1998
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负责人:Lawrence A. Tabak
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依托单位:
GORDON CONFERENCE ON SALIVA AND SALIVARY GLANDS
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批准号:2015505
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项目类别:
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资助金额:$1.5万
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财政年份:1997
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负责人:Lawrence A. Tabak
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依托单位:
DEVELOPMENTAL GRANT FOR THE ROCHESTER COHRCD
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批准号:2397507
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项目类别:
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资助金额:$15.9万
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财政年份:1997
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负责人:Lawrence A. Tabak
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依托单位:
SALIVARY ARGININE/LYSINE/PEPTIDES AND CARIES EXPERIENCE
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批准号:6238576
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项目类别:
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资助金额:$16.86万
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财政年份:1997
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负责人:Lawrence A. Tabak
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依托单位:
REGULATION OF SALIVARY GLAND-SPECIFIC GENE EXPRESSION
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批准号:3223972
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项目类别:
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资助金额:$19.04万
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财政年份:1993
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负责人:Lawrence A. Tabak
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依托单位:
REGULATION OF SALIVARY GLAND-SPECIFIC GENE EXPRESSION
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批准号:2331322
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项目类别:
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资助金额:$22.42万
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财政年份:1993
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负责人:Lawrence A. Tabak
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依托单位:
REGULATION OF SALIVARY GLAND-SPECIFIC GENE EXPRESSION
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批准号:2131376
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项目类别:
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资助金额:$20.59万
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财政年份:1993
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负责人:Lawrence A. Tabak
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依托单位:
REGULATION OF SALIVARY GLAND-SPECIFIC GENE EXPRESSION
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批准号:2131377
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项目类别:
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资助金额:$21.55万
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财政年份:1993
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负责人:Lawrence A. Tabak
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依托单位:
REGULATION OF SALIVARY GLAND-SPECIFIC GENE EXPRESSION
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批准号:2131375
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项目类别:
-
资助金额:$19.8万
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财政年份:1993
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY
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批准号:3534469
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项目类别:
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资助金额:$19.53万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT
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批准号:2129649
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项目类别:
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资助金额:$25.5万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT
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批准号:2129648
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项目类别:
-
资助金额:$19.43万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT
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批准号:2129651
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项目类别:
-
资助金额:$22.42万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY
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批准号:3534468
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项目类别:
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资助金额:$17.77万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY
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批准号:3534467
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项目类别:
-
资助金额:$9.51万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT
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批准号:2129650
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项目类别:
-
资助金额:$26.44万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT
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批准号:2683955
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项目类别:
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资助金额:$24.82万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
ORAL CELLULAR AND MOLECULAR BIOLOGY TRAINING GRANT
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批准号:2391174
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项目类别:
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资助金额:$23.49万
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财政年份:1990
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负责人:Lawrence A. Tabak
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依托单位:
国内基金
海外基金
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
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批准号:81973577
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项目类别:面上项目
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资助金额:55.0万元
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批准年份:2019
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负责人:辛贵忠
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依托单位: