TROPHIC FACTOR/TRANSMITTER INTERACTIONS IN ADDICTION

这是对NIDA RFA的回应，用于建立神经科学 网络该提案包含一系列高度相互交叉的 这些项目在科学和技术上都有联系。重大主题 神经营养因子的作用贯穿于这四个项目 以及与药物滥用相关的神经系统细胞因子。第二主 贯穿四个项目中三个项目的主题是 中脑边缘多巴胺系统的神经递质和营养因子。一 将两个项目紧密联系在一起的第三个主题是研究 胆碱能-多巴胺能相互作用。该网络涉及全新的 两个实验室已经参与了药物滥用研究， 两个著名的神经科学家的实验室， 第一次研究。所有调查员的主要联系 是他们致力于使用分子和细胞工具， 了解大脑和行为的服务。调查人员，谁 包括一个高度合议的小组，彼此都很熟悉， 特别热衷于通信核心， 促进他们一起工作。该RFA为以下方面提供了机会： 小组发展跨越物理距离的协同互动 这将加速他们对宇宙中基本过程的研究， 与滥用药物的行为有关的神经系统。

This is a response to a NIDA RFA for the establishment of a Neuroscience Network. This proposal contains a series of highly interdigitated projects, connected both scientifically and technically. The major theme running through all four projects is the action of neurotrophic factors and cytokines in neural systems relevant to drug abuse. A second major theme running through three of the four projects is modulation of mesolimbic dopamine systems by neurotransmitters and trophic factors. A third theme binding two of the projects closely together is the study of cholinergic-dopaminergic interactions. The Network involves entirely new project from two labs already involved in drug abuse research and recruits the laboratories of two well established neuroscientists to drug abuse research for the first time. A major connection of all the investigators is their commitment to the use of molecular and cellular tools in the service of understanding brain and behavior. The investigators, who comprise a highly collegial group, well known to each other, are particularly enthusiastic about the communications core which will facilitate their work together. This RFA has provided an opportunity for the group to develop synergistic interactions across physical distance that will speed their investigations of fundamental processes in the nervous system relevant to the actions of drugs of abuse.