CAUSES OF VARIATION IN SECONDARY METABOLITE BY TROPICAL MARINE ORGANISMS

热带海洋生物次级代谢产物变化的原因

• 批准号: 6204220
• 负责人: VALERIE Jean PAUL
• 金额: $ 7.01万
• 依托单位: UNIVERSITY OF GUAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6204220
• 关键词: Invertebrata; Porifera; alternatives to animals in research; animal population study; antiinflammatory agents; antineoplastics; aquatic organism; biological products; biosynthesis; chemical structure function; coral; drug screening /evaluation; environmental stressor; food chain; life cycle; lighting; marine biology; pharmacology; physical chemical interaction; plant extracts; plants; saltwater environment

This research will examine the importance of biological and physical causes of variation in the production of bioactive secondary metabolities by tropical seaweeds (including benthic, filamentous cyanobacteria) and invertebrates. The research has important biomedical consequences because it will specifically search for marine natural products with solid tumor selectivity (through NCI-sponsored research in collaboration with Dr. Fred Valeriote at Wayne State University Medical School), and it will focus on understanding what factors affect the yields of biomedically important marine natural products. First, differences in types and concentrations of secondary metabolites at different ages and life history stages, and among populations of selected seaweeds and invertegrateswill be examined. Facultative changes in chemical defenses will be examined for seaweeds, sponges, and soft corals exposed to: 1) increased grazing by fishes and specialist predators; and 2) different resources levels of light and nutrients. The proposed research will provide information on chemical variation and its causes and the ability and timing of seaweeds and invertebrates to change their allocation of chemical defenses. The study will contribute to our limited knowledge of the chemical variability of seaweeds and marine invertebrates, the biological properties of marine natural products, and the relationship between natureal adaptive functions of secondary metaolites and their biomedical potential. All extracts and isolated metabolies will be incorporated into established testing programs (UC Santa Barbara, Wayne State University Medical School) to determine their pharmacological activities in assays examining anti-inflammatory activity and solid tumor selectivity. Funding is requested primarily for personnel and supplies to carry out this Associate Investigator research. This program will provide research training opportunities for minority undergraduate and graduate (M.S. degree) students at the University of Guam, a predominantly undergraduate and minority institution.

这项研究将研究生物学和物理的重要性 生物活性次级产生变化的原因 热带海藻的代谢（包括底栖，丝状 蓝细菌）和无脊椎动物。 这项研究很重要 生物医学后果，因为它会专门寻找海洋 具有实体肿瘤选择性的天然产品（通过NCI赞助 与韦恩州立大学的弗雷德·瓦雷奥特（Fred Valeriote）博士合作的研究 大学医学院），它将专注于了解什么 因素会影响生物医学重要的海洋自然的产量 产品。首先，次要的类型和浓度差异 不同年龄和生活历史阶段的代谢产物以及 将检查选定的海藻和无覆盖物的种群。 将检查化学辩护的兼性变化 海藻，海绵和软珊瑚暴露于：1）放牧增加 由鱼类和专业捕食者； 2）不同的资源水平 光和营养。拟议的研究将提供信息 关于化学变化及其原因以及 海藻和无脊椎动物改变其化学分配 防御。 这项研究将有助于我们对 海藻和海洋无脊椎动物的化学变异性， 海洋天然产物的生物学特性和关系 在次级元石的自然自适应功能及其之间 生物医学潜力。 所有提取物和孤立的代谢将是 纳入已建立的测试计划（UC Santa Barbara， 韦恩州立大学医学院）确定 检查抗炎的测定中的药理学活动 活性和实体瘤的选择性。 主要要求资金 用于人员和用品来执行这位副调查员 研究。 该计划将提供研究培训机会 对于少数族裔本科和研究生（M.S.学位）学生 关岛大学，主要是本科和少数派 机构。