ECHOCARDIOGRAPHY WORKSTATION FOR ANIMAL RESEARCH

一组多学科研究人员正在申请资金，用于购置超声成像系统（Acuson Sequoia[模型C256]），以获得小动物模型的超声心动图。超声心动图或超声成像是一种无创的原位测量心脏解剖和功能的方法。这个多学科小组将使用大鼠和小鼠转基因模型来检查与正常和病理性心血管疾病相关的心脏结构和功能的变化，但有单独的国家卫生研究院支持的研究项目。m型定向、二维定向和脉冲波多普勒超声心动图记录将用于获取心脏解剖和功能的信息。总共有8个主要用户将使用超声心动图系统。这样一台机器和中心位置（生物资源实验室）的可用性将大大提高本资助提案参与者的研究生产力。此外，由于能够对一只动物进行连续测量，每个方案牺牲的动物数量将减少。大约60%的仪器时间将用于博士的研究。皮亚诺（PI），巴特里克（PI）和索拉罗（PI），他们都是现有NIH拨款的主要调查员。剩余的40%超声心动图成像系统时间将由dr。Geenen, Hickson, Arteaga， Varga和Schwertz。超声心动图工作站将在dr。彼得·瓦尔加，儿科心脏病专家，还有泰勒·贝内特。长期维护将由生物资源实验室在泰勒·贝内特博士的指导下负责。班纳特主任已经任命了一个咨询委员会来制定运营指南和用户费用。总之，伊利诺伊大学芝加哥分校没有可用于动物研究的带有高频换能器的超声心动图机。一组多学科研究人员将只在他们的大鼠和小鼠模型中使用该系统进行小动物研究。

A group of multidisciplinary researchers are requesting funds for the acquisition of an ultrasound imaging system (Acuson Sequoia [model C256]) to obtain echocardiograms in small animal models. Echocardiography or ultrasound imaging is a noninvasive method for the in situ measurement of cardiac anatomy and function. Collectively, but with separate National Institutes of Health supported research programs, this multidisciplinary group will use rat and murine transgenic models to examine changes in cardiac structure and function that are associated with normal, as well as pathological cardiovascular conditions. M-mode directed, two-dimensional directed and pulse wave Doppler echocardiographic recordings will be used to obtain information on cardiac anatomy and function. Altogether, eight major users will be utilizing the echocardiography system. The availability of such a machine and central location (Biological Resource Laboratory) will greatly enhance the research productivity of the participants in this grant proposal. In addition, because of the ability to make serial measurements in one animal, the number of sacrificed animals per protocol will decrease. Approximately 60 percent of the instrument time will be devoted to the research of Drs. Piano (PI), Buttrick (PI) and Solaro (PI), all of whom are primary investigators on existing NIH grants. The remaining 40 percent of the echocardiography imaging system time will be utilized by Drs. Geenen, Hickson, Arteaga, Varga, and Schwertz. The echocardiography workstation will be operated under the direction of Drs. Peter Varga, pediatric cardiologist, and Taylor Bennet. Long term maintenance will be the responsibility of the Biologic Resources Laboratory under the direction of Dr. Taylor Bennet. Director Bennet has appointed an advisory committee to set operation guidelines and user fees. In conclusion, the University of Illinois at Chicago has no echocardiography machine with a high frequency transducer available for animal research. A group of multidisciplinary researchers will use this system only for small animal research in their rat and murine models.