LSU DENTAL COBRE: BIOMEDICAL EQUIPMENT CORE

LSU Dental COBRE：生物医学设备核心

• 批准号: 7382151
• 负责人: Thomas E Lallier
• 金额: $ 37.75万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382151
• 关键词: LSU; DENTAL; COBRE; BIOMEDICAL; EQUIPMENT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Periodontal disease afflicts nearly 30% of the adult population and is a main cause of tooth loss. The susceptibility of the gingival tissues to plaque-induced periodontal disease may be influenced by the aging process. We hypothesize that aging of periodontal tissues causes changes in the expression of proteins critical for inflammation and tissue regeneration. This results in greater disease susceptibility and lower healing potential in aged subjects. To test this hypothesis, biopsies of gingival tissue from young and aged subjects will be used to examine the expression of inflammatory cytokines and growth factors. The results are expected to serve as a basis for developing novel approaches for therapeutic intervention in periodontitis that may lead to improved periodontal therapies and tooth retention. To this end, the following is the progress for year 1. Objective: To prepare a protocol to study the effects of aging on periodontal disease; to set up the laboratory with the necessary equipment; to become educated as a scientific investigator. Methods: Worked with the mentoring team to prepare the proposal for the COBRE and set up the lab; attended COBRE program sessions. Results: The proposal was approved by the External Advisory Committee (EAC) with minor revisions. The grant was subsequently approved by the NIH an amended award notice was recently received. The protocol also obtained approval by the IRB. Lab space was renovated and the laboratory is being set up, with most equipment already in place. Two research associates (100% and 50% effort) were hired. The PI and the associates are optimizing the laboratory techniques necessary for the project. The PI participated in COBRE sponsored activities, such as the monthly journal club, the grant seeker sessions, the comprehensive clinical training course, and progress reports and presentations. Discussion: The PI with constant cooperation with the mentoring team and the EAC have already clarified methodology issues. Pilot studies are being set-up and the research team is preparing to recruit patients.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。介绍：牙周病困扰着近30%的成年人，是牙齿脱落的主要原因。牙龈组织对牙菌斑引起的牙周病的易感性可能受到年龄过程的影响。我们推测牙周组织的老化导致炎症和组织再生关键蛋白质表达的变化。这导致老年受试者的疾病易感性更高，愈合潜力更低。为了验证这一假设，将使用年轻和老年受试者的牙龈组织活检来检查炎性细胞因子和生长因子的表达。这些结果有望成为开发牙周炎治疗干预新方法的基础，从而改善牙周治疗和牙齿保留。 为此，以下是第一年的进展情况。 目的：准备一份研究衰老对牙周病影响的协议;建立实验室，配备必要的设备;成为受过教育的科学调查员。方法：与指导团队一起准备COBRE的提案并建立实验室;参加COBRE项目会议。结果：外部咨询委员会（EAC）批准了该提案，但略有修改。该补助金随后得到了美国国立卫生研究院的批准，最近收到了修改后的奖励通知。该方案还获得了IRB的批准。实验室空间已经翻新，实验室正在建立中，大部分设备已经到位。两名研究助理（100%和50%的努力）被雇用。PI和同事正在优化项目所需的实验室技术。PI参加了COBRE赞助的活动，如月刊俱乐部、赠款申请者会议、综合临床培训课程以及进度报告和演示。讨论：PI与指导团队和EAC的持续合作已经澄清了方法问题。试点研究正在进行中，研究小组正准备招募患者。