INTEGRATED XRAY IMAGE PLATE DETECTOR SYSTEM

集成 X 射线图像板检测器系统

• 批准号: 2766457
• 负责人: STEVEN C. ALMO
• 金额: $ 25.94万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-20 至 2000-01-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2766457
• 关键词: X ray crystallography; bioimaging /biomedical imaging; biomedical equipment purchase; radiation detector; structural biology

We are requesting funds to purchase state of the art x-ray data collection instrumentation, including an image plate detector, rotating anode x-ray generator and associated optics and cooling components. The multi-wire instrumentation currently at the College is nearing 10 years old and is a generation behind existing state of the art facilities which are to be found at most academic and industrial research laboratories. We are thus at a severe disadvantage with respect to our colleagues and competitors at a time when a series of exciting and important structures are about to be solved. These requested components are essential to the continued vigor and development of structural biology at the College of Medicine. The proposed instrumentation will relieve a bottleneck in data collection which is caused by the large structural community at the College of Medicine. The spatial resolution, overall efficiency and enhanced solid angle of the proposed detector will allow for more rapid and efficient collection of x-ray diffraction data with improved statistical accuracy. These features will directly impact our ability to solve new structures, and will allow for high resolution refinements which are critical for understanding chemistry and biology. The proposed detector system will complement the College's NIH funded Research Resource located at Brookhaven National Laboratory and will allow for optimal use of these facilities.

我们正在申请资金，以购买最先进的X射线数据收集仪器，包括图像板探测器、旋转阳极X射线发生器以及相关的光学和冷却部件。 目前在学院的多线仪器已近10年的历史，是落后于现有的最先进的设施，这是在大多数学术和工业研究实验室发现的一代。 因此，在一系列令人兴奋的重要结构即将解决之际，我们与同事和竞争对手相比处于严重的劣势。 这些要求的组成部分是必不可少的持续活力和结构生物学在医学院的发展。拟议的仪器将缓解数据收集的瓶颈，这是由在医学院的大型结构社区。 所提出的检测器的空间分辨率、整体效率和增强的立体角将允许以改进的统计精度更快速和有效地收集X射线衍射数据。 这些特征将直接影响我们解决新结构的能力，并将允许高分辨率的改进，这对理解化学和生物学至关重要。 拟议的探测器系统将补充学院的NIH资助的研究资源位于布鲁克海文国家实验室，并将允许最佳利用这些设施。