INTEGRATED XRAY IMAGE PLATE DETECTOR SYSTEM

我们正在申请资金，以购买最先进的X射线数据收集仪器，包括图像板探测器、旋转阳极X射线发生器和相关的光学和冷却部件。目前学院的多线仪器已有近10年的历史，比大多数学术和工业研究实验室中现有的最先进的设备落后了一代。因此，在一系列令人兴奋和重要的结构即将得到解决的时候，我们相对于我们的同事和竞争对手处于严重的劣势。这些所要求的组成部分对于医学院结构生物学的持续活力和发展至关重要。拟议的仪器将缓解由于医学院庞大的结构社区而造成的数据收集瓶颈。拟议的探测器的空间分辨率、总体效率和增强的立体角将允许更快速、更有效地收集X射线衍射数据，并提高统计精度。这些功能将直接影响我们解决新结构的能力，并将允许高分辨率的细化，这对理解化学和生物学至关重要。拟议的探测器系统将补充学院位于布鲁克海文国家实验室的NIH资助的研究资源，并将允许最佳利用这些设施。

We are requesting funds to purchase state of the art x-ray data collection instrumentation, including an image plate detector, rotating anode x-ray generator and associated optics and cooling components. The multi-wire instrumentation currently at the College is nearing 10 years old and is a generation behind existing state of the art facilities which are to be found at most academic and industrial research laboratories. We are thus at a severe disadvantage with respect to our colleagues and competitors at a time when a series of exciting and important structures are about to be solved. These requested components are essential to the continued vigor and development of structural biology at the College of Medicine. The proposed instrumentation will relieve a bottleneck in data collection which is caused by the large structural community at the College of Medicine. The spatial resolution, overall efficiency and enhanced solid angle of the proposed detector will allow for more rapid and efficient collection of x-ray diffraction data with improved statistical accuracy. These features will directly impact our ability to solve new structures, and will allow for high resolution refinements which are critical for understanding chemistry and biology. The proposed detector system will complement the College's NIH funded Research Resource located at Brookhaven National Laboratory and will allow for optimal use of these facilities.