An integrated X-ray data collection system
集成 X 射线数据采集系统
基本信息
- 批准号:9145388
- 负责人:
- 金额:$ 30万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-04-01 至 2016-03-31
- 项目状态:已结题
- 来源:
- 关键词:AnatomyAnodesAreaAutoimmunityBiochemistryBiologyBiophysicsCommunicable DiseasesCommunitiesCoupledData CollectionDevelopmentDiagnostic radiologic examinationEcologyEpigenetic ProcessEquipmentFundingGrantHousingHumanImmunityImmunologyInstitutesInstitutionLaboratoriesLightMalignant NeoplasmsMedicineMicrobiologyMissionNeurosciencesNew YorkOpticsPeripheralPhotonsPhysiologyRNARegulationResearchRoentgen RaysServicesSourceSynchrotronsSystemSystems Biologyagedcollegedetectordrug discoveryinstrumentationmacromolecular assemblymeetingsprogramsstructural biology
项目摘要
DESCRIPTION (provided by applicant): In 1999 the Albert Einstein College of Medicine successfully competed for a Shared Instrumentation Grant entitled "Integrated X-ray Image Plate Detector System" (1S10RR013658-01; Almo, PI). This system has been in continuous use and supported an enormously broad and productive structural biology community for the past ~14 years. The Albert Einstein College of Medicine is now requesting funds to purchase a state-of-the-art X-ray data collection system, including a MicroMax"-007 HF rotating anode generator, a VariMax" optic, AFC11 4-axis goniometer, Dectris Pilatus P200K detector, Oxford Cryosystems Cryostream and associated peripherals. This instrumentation fills four critical needs: 1) our existing equipment has aged to the point that service and replacement parts can no longer be guaranteed; 2) the need for enhanced in-house data collection capabilities to support the numerous structural biology programs at the College; 3) the need to identify alternative data collection opportunities due to the imminent closure of the National Synchrotron Light Source (NSLS), which is the major data collection venue for the entire structural biology community at the College; and 4) the need to meet the growing institutional educational mission. The considerable flux of the MicroMax"-007 coupled with the photon counting capabilities of the Pilatus P200K detector results in data collection rates that are two orders of magnitude greater than those afforded by our existing system. This enhancement provides new opportunities for in-house data collection that will significantly impact the efficiency and rate at which the many structural biology programs are prosecuted at the Albert Einstein College of Medicine. These capabilities will benefit the research programs of 24 laboratories in 10 departments (Einstein Biochemistry, Anatomy & Structural Biology, Physiology & Biophysics, Medicine, Microbiology & Immunology, and Neuroscience; 4 departments at nearby institutes) at 5 New York area institutions (Einstein, Brooklyn CUNY, Rockefeller, Hofstra, and Brookhaven National Laboratory). These programs span a wide range of cutting-edge biomedical areas, including human immunity, cancer, autoimmunity, infectious disease, macromolecular assembly, function and regulation, transition state analysis, drug discovery, RNA biology, epigenetics, functional annotation, environmental science and systems biology. The requested X-ray data collection system will have broad scientific impact and is essential for the continued vigor and development of structural biology at the Albert Einstein College of Medicine and neighboring institutions.
描述(由申请人提供):1999年,阿尔伯特·爱因斯坦医学院成功获得了题为“集成X射线图像板探测器系统”(1 S10 RR 013658 -01; Almo,PI)的共享仪器资助。在过去的14年里,该系统一直在持续使用,并支持了一个非常广泛和富有成效的结构生物学社区。阿尔伯特·爱因斯坦医学院目前正在申请资金,以购买最先进的X射线数据收集系统,包括MicroMax-007高频旋转阳极发生器、VariMax光学器件、AFC 11 4轴测角仪、Dectris Pilatus P200 K探测器、Oxford Cryosystems Cryostream和相关外围设备。该仪器满足了四个关键需求:1)我们现有的设备已经老化到无法保证服务和更换部件的程度; 2)需要增强内部数据收集能力,以支持学院的众多结构生物学课程; 3)由于国家同步加速器光源(NSLS)即将关闭,需要确定替代数据收集机会,这是整个结构生物学社区在学院的主要数据收集场所;和4)需要满足日益增长的机构教育使命。MicroMax”-007的可观通量与Pilatus P200 K探测器的光子计数能力相结合,导致数据收集速率比我们现有系统提供的数据收集速率高两个数量级。这种增强为内部数据收集提供了新的机会,这将显著影响阿尔伯特·爱因斯坦医学院许多结构生物学项目的效率和速度。这些能力将有利于5个纽约地区机构(爱因斯坦、布鲁克林市立大学、洛克菲勒、霍夫斯特拉和布鲁克海文国家实验室)10个部门(爱因斯坦生物化学、解剖学与结构生物学、生理学与生物物理学、医学、微生物学与免疫学和神经科学;附近研究所的4个部门)的24个实验室的研究计划。这些计划涵盖了广泛的前沿生物医学领域,包括人类免疫,癌症,自身免疫,传染病,大分子组装,功能和调节,过渡态分析,药物发现,RNA生物学,表观遗传学,功能注释,环境科学和系统生物学。所要求的X射线数据收集系统将具有广泛的科学影响,对于阿尔伯特·爱因斯坦医学院和邻近机构的结构生物学的持续活力和发展至关重要。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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STEVEN C. ALMO其他文献
STEVEN C. ALMO的其他文献
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