NEW MULTIVARIATE TECHNIQUES FOR CALCULATION OF BLOOD ANALYTE CONCENTRATIONS

在这个项目中，我们正在开发一种监测血液的方法 使用近红外拉曼光谱检测分析物。到目前为止，我们集中精力 在体外对血清和全血样本进行检测。我们已经证明了 能够对多种分析物(葡萄糖、总蛋白、 白蛋白、总胆固醇、甘油三酯和尿素)与临床 血清样本的准确性。我们也有了初步的结果 包括对全血样本的成功预测。目前， 我们正在努力设计更好的全血校准，服用 考虑到这种介质的额外复杂性。下一个目标是 为经皮研究做准备。

In this project, we are developing a way of monitoring blood analytes using NIR Raman spectroscopy. Thus far, we have concentrated on blood serum and whole blood samples in vitro. We have demonstrated the ability to quantitate multiple analytes (glucose, total protein, albumin, total cholesterol, triglycerides, and urea) with clinical accuracy in blood serum samples. We also have preliminary results involving successful predictions in whole blood samples. Currently, we are trying to design better calibrations in whole blood, taking into account the added complexities of this medium. The next goal is to prepare for transcutaneous studies.