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RAMAN SPECTROSCOPY FOR BREAST CANCER DETECTION VIA PRINCIPAL COMPONENT ANALYSIS

RAMAN SPECTROSCOPY FOR BREAST CANCER DETECTION VIA PRINCIPAL COMPONENT ANALYSIS
通过主成分分析进行乳腺癌检测拉曼光谱
批准号：
6121228
负责人：
KAREN SHAFER
金额：
$0.82万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-06-01 至 2000-05-31
来源：
https://reporter.nih.gov/project-details/6121228
关键词：
bioimaging /biomedical imaging biomedical equipment development biomedical resource cardiovascular system human tissue microscopy spectrometry technology /technique

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英文摘要
A confocal Raman spectroscopy was developed with 830 nm laser excitation. High Raman spectra of various morphological structures in arterial wall such as elastic lamina, collagen fibers, adventitial fat, cholesterol crystals, foam cells and calcium mineralization. The objective the present estimate quantitative biochemical composition of each of the morphological structures present in tissues. We used a least square minimization routine to model spectra of morphological structure in terms of nine biochemical such as collagen, elastin, triolein, cholesterol, cholesterol linoleate, phosphatidyl choline, b-carotene, calcium hydroxy apatite, and calcium carbonate. Near perfect fit were obtained for each morphological structure studied and chemical composition was determined. Comparison of these results provided detailed information about intra and inter structural chemical variations at different stages of atherosclerosis.
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