DEVELOPMENT OF RAMAN SPECTROSCOPY FOR IN VIVO DIAGNOSIS BREAST CANCER

本项目的目标是开发基于拉曼的 乳房组织的实时、原位诊断技术 针吸活组织检查或手术。我们之前已经证明了拉曼 光谱分析可用于现场组织化学分析 生物组织。该项目的第一部分涉及到设计 一种光纤针尖探头，能够传递和收集 对正在研究的组织进行必要的照射。第二部分 取决于乳房分类算法的发展 基于其拉曼光谱的组织。我们已经确定 疾病分类所需的信息包含在 拉曼光谱。现在我们需要确定哪些化学物质是 对拉曼光谱中的这些差异负责，并开发出一种 决策算法。同时，我们正在设计一种适当的 用于获得活体拉曼光谱的探针。

The objective of this project is to develop a Raman based technique for real-time, in situ diagnosis of breast tissue during needle biopsy or surgery. We have previously shown that Raman spectroscopy can be used for in situ histochemical analysis of biological tissue. The first part of this project involves the design of a fiber-optic needle probe capable of delivering and collecting the necessary light to the tissue being studied. The second portion depends on the development of an algorithm for classifying breast tissue based on its Raman spectra. We have already established that the information necessary for disease classification is contained in the Raman spectra. Now we need to determine which chemicals are responsible for these differences in the Raman spectra and develop a decision algorithm. Simultaneously, we are designing an appropriate probe for obtaining in vivo Raman spectra.