DEVELOPMENT OF RAMAN SPECTROSCOPY FOR IN VIVO DIAGNOSIS BREAST CANCER

该项目的目标是开发基于拉曼的 实时、原位诊断乳腺组织的技术 针吸活检或手术。 我们之前已经证明拉曼 光谱学可用于原位组织化学分析 生物组织。 该项目的第一部分涉及设计 能够传输和收集光纤针探针 所研究组织所需的光线。 第二部分 取决于乳房分类算法的开发 基于其拉曼光谱的组织。 我们已经确定 疾病分类所需的信息包含在 拉曼光谱。 现在我们需要确定哪些化学品是 造成拉曼光谱中的这些差异并开发了一个 决策算法。 同时，我们正在设计一个合适的 用于获得体内拉曼光谱的探针。

The objective of this project is to develop a Raman based technique for real-time, in situ diagnosis of breast tissue during needle biopsy or surgery. We have previously shown that Raman spectroscopy can be used for in situ histochemical analysis of biological tissue. The first part of this project involves the design of a fiber-optic needle probe capable of delivering and collecting the necessary light to the tissue being studied. The second portion depends on the development of an algorithm for classifying breast tissue based on its Raman spectra. We have already established that the information necessary for disease classification is contained in the Raman spectra. Now we need to determine which chemicals are responsible for these differences in the Raman spectra and develop a decision algorithm. Simultaneously, we are designing an appropriate probe for obtaining in vivo Raman spectra.